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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Differential effects of low versus high doses of apomorphine on retinal dopamine metabolism in light- and dark-adapted rabbits.
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Differential effects of low versus high doses of apomorphine on retinal dopamine metabolism in light- and dark-adapted rabbits.

机译：低剂量和高剂量阿扑吗啡对浅色和深色适应兔视网膜多巴胺代谢的差异作用。

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摘要

Previous electrophysiologic results from this laboratory indicate that apomorphine exerts a differential dose-related effect on rabbit electroretinograms, with low doses increasing the b-wave and higher doses decreasing this parameter. Results were interpreted as reflecting apomorphine's agonistic properties at two different receptors: 1.0 mg/kg acting at the postsynaptic site, and the lower dose, 0.01 mg/kg, preferentially stimulating inhibitory autoreceptors. The purpose of this experiment was to investigate further this hypothesis by determining retinal levels of dopamine, dihydroxyphenylacetic acid, and homovanillic acid in retinas of light- or dark-adapted rabbits treated with saline, 1.0, 0.1, or 0.01 mg/kg apomorphine intravenously. Results indicate that in dark-adapted rabbits only the highest dose tested, 1.0 mg/kg, decreased dopamine concentrations. In animals exposed to light, the lowest dose tested, 0.01 mg/kg, significantly reduced dopamine and metabolite levels, whereas the highest dose unexpectedly increased retinal dopamine turnover. Results are discussed in terms of receptor sites and the influence of lighting conditions.
机译：该实验室先前的电生理结果表明，阿扑吗啡对家兔视网膜电图具有不同的剂量相关作用，低剂量会增加b波，高剂量会降低该参数。结果被解释为反映了阿扑吗啡在两种不同受体上的激动特性：作用于突触后位点的剂量为1.0 mg / kg，而较低剂量的剂量为0.01 mg / kg，优先刺激抑制性自体受体。本实验的目的是通过确定经盐水，1.0、0.1或0.01 mg / kg的阿扑吗啡静脉处理的浅色或深色适应兔视网膜中的多巴胺，二羟苯基乙酸和高香草酸的视网膜水平，进一步研究该假设。结果表明，在适应黑暗的兔子中，仅测试的最高剂量1.0 mg / kg降低了多巴胺浓度。在光照下的动物中，最低测试剂量0.01 mg / kg显着降低了多巴胺和代谢产物的水平，而最高剂量却意外地增加了视网膜多巴胺的更新。根据受体部位和光照条件的影响来讨论结果。

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