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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Dopamine agonists prevent or counteract the suppression of brain stimulation reward by fenfluramine.
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Dopamine agonists prevent or counteract the suppression of brain stimulation reward by fenfluramine.

机译：多巴胺激动剂可预防或抵消芬氟拉明对脑刺激奖励的抑制作用。

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The interaction between the serotonin (5-HT) and the dopamine (DA) systems in the modulation of intracranial self-stimulation (ICSS), a DA-dependent behavior, was investigated. Chronically implanted rats for ICSS in the medial forebrain bundle were tested for the effects of fenfluramine at a dose of 20 mg/kg, and then for the effects of 10 mg/kg piribedil plus 2 mg/kg amphetamine, injected 30 min before fenfluramine or 60 min after fenfluramine. Our aim was to determine whether the action of fenfluramine at the DA binding site could be blocked by prior occupation, or whether if it were occupied by fenfluramine it could be reversed. Fenfluramine, 20 mg/kg, injected alone, suppressed ICSS for 5-7 h. The suppression was followed by a prolonged recovery during which ICSS was profounded depressed. Repeating the treatment 7 days later produced the same response, except that the suppression was of shorter duration. In another group of animals, pretreatment with piribedil plus amphetamine 30 min before fenfluramine prevented the suppression of ICSS. Instead, ICSS was briefly attenuated, then restored to baseline levels, and then facilitated. Repeating the treatment 7 days after the first treatment potentiated this response. The attenuation was now even briefer, the recovery more rapid, and the facilitation more robust. In still another group of animals, fenfluramine was given just before the ICSS session began. Predictably, the effect was a total cessation of ICSS. At 60 min into the session, piribedil plus amphetamine was injected. The response showed a rapid recovery of ICSS followed by facilitation.(ABSTRACT TRUNCATED AT 250 WORDS)
机译：研究了血清素（5-HT）和多巴胺（DA）系统在颅内自我刺激（ICSS）的调节中的相互作用，这是DA依赖的行为。长期植入内侧前脑束中的ICSS的大鼠接受20 mg / kg剂量的芬氟拉明的作用，然后在fenfluramine或fenfluramine之前30分钟注射10 mg / kg的哌立贝定和2 mg / kg的苯丙胺的作用进行测试。芬氟拉明后60分钟。我们的目的是确定芬氟拉明在DA结合位点的作用是否可以被先前的占领所阻断，或者是否被芬氟拉明所占据而可以逆转。单独注射芬氟拉明20 mg / kg，可抑制ICSS 5-7 h。压制之后是长期恢复，在此期间ICSS变得极为沮丧。 7天后重复治疗产生相同的反应，除了抑制作用持续时间较短。在另一组动物中，在联苯氟拉明之前30分钟用哌立比尔和苯丙胺进行预处理可防止ICSS的抑制。相反，对ICSS进行了短暂衰减，然后恢复到基线水平，然后进行了简化。在第一个治疗后7天重复治疗可增强这种反应。现在衰减更短，恢复更快，促进更可靠。在另一组动物中，在ICSS会议开始前给予了芬氟拉明。可以预见，其效果是完全停止了ICSS。疗程结束后60分钟，注射了匹立贝定加苯丙胺。回复显示ICSS迅速恢复，随后得到了协助。（摘要截断为250字）

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