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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Play behavior and stress responsivity in periadolescent offspring exposed prenatally to cocaine.
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Play behavior and stress responsivity in periadolescent offspring exposed prenatally to cocaine.

机译：产前暴露于可卡因的青春期后代的游戏行为和应激反应。

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Play behavior and stress responsiveness were examined in offspring exposed gestationally to cocaine. The subjects were offspring of Sprague-Dawley rat dams given s.c. injections of 40 mg/kg/3 cc cocaine HC1 daily from gestational days 8-20 (C40), pair-fed dams injected daily with saline (PF), and untreated control dams (LC). Periadolescent (postnatal day (P) 30-36) male and female rats were assigned to either pretest Stress or No Stress conditions. Every other day Stress animals were exposed to a stressor (on P30--foot shock; P32--white noise; P34--forced swim; P36--foot shock), with each stressor being administered 4 h prior to a play session. Immobility during one of the stressors, foot shock, was used to assess stress responsiveness. Play sessions consisted of pairing each experimental animal with a same-sex, nonexperimentally manipulated conspecific for 7 min. The results indicated that periadolescent offspring exposed gestationally to cocaine differed from controls in their stress responsivity, asevidenced by a failure to show increased immobility during the final foot shock session. Also, while cocaine-exposed juveniles did not differ from controls in their own play behavior, these offspring elicited less play solicitation from conspecifics, as evidenced by an increased latency to be pounced, and decreased frequency and duration of being pounced. These findings parallel earlier evidence for altered stress responsiveness in adult cocaine-exposed rats and also suggest that prenatal exposure to cocaine results in altered social cues.
机译：研究了妊娠期暴露于可卡因的后代的游戏行为和应激反应。受测者是Sprague-Dawley大鼠水坝的后代。从孕8-20天开始每天注射40 mg / kg / 3 cc可卡因HCl（C40），成对喂养的母犬每天注射盐水（PF）和未经处理的对照母犬（LC）。雌性青春期（出生后（P）30-36天）的雄性和雌性大鼠被分配到预测试压力或无压力条件下。每隔一天，压力动物会受到压力刺激（在P30--足部休克; P32--白噪声; P34--强迫游泳; P36--足部休克），在比赛前4小时对每个压力源进行管理。在其中一种压力源（脚震）中的不动被用来评估压力反应性。游戏过程包括将每只实验动物与同性，未经实验操作的同种配对配对7分钟。结果表明，妊娠期暴露于可卡因的青春期后代与对照组相比，其应激反应性有所不同，这是由于在最后一次脚底休克期间未能显示出增加的运动能力所证明的。同样，虽然可卡因接触的幼虫在玩耍行为上与对照组没有区别，但这些后代从同种动物中引起的玩耍诱因减少了，如被突击的潜伏期增加，被突击的频率和持续时间减少所证明。这些发现与早期证据表明暴露于成年可卡因的大鼠的应激反应改变有关，也表明产前暴露于可卡因会导致社会暗示改变。

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