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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Autosomal and Y chromosomal effects on the stereotyped response to apomorphine in wild house mice.
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Autosomal and Y chromosomal effects on the stereotyped response to apomorphine in wild house mice.

机译：常染色体和Y染色体对野生型小鼠对阿扑吗啡定型反应的影响。

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摘要

The behavioral response to apomorphine, a dopamine agonist, was shown to be different between a selection line characterized by Short Attack Latencies (SAL) and a selection line having Long Attack Latencies (LAL) (4). Aggressive SAL mice were more sensitive to apomorphine than nonaggressive LAL males. The aim of this research was to determine whether the stereotyped response to apomorphine is affected by the Y chromosome in the same way as it influences attack latency. For this purpose, F1 reciprocal hybrids as well as congenic lines (SAL.LY and LAL.SY) were used. The major difference between the congenic and parental lines is the nonpairing part of the Y chromosome (non-PAR). Apomorphine was injected subcutaneously at a preselected dose level of 5.0 mg/kg to induce stereotyped behavior manifested in compulsive sniffing, gnawing, and licking. Both the autosomes and the non-PAR Y chromosome affected the response to apomorphine. The effect of the autosomes was in accordance with the aggression data, whereas the effect of the non-PAR Y chromosome was different, and suggests a specific relation between dopamine systems and the non-PAR Y chromosome.
机译：对多巴胺激动剂阿扑吗啡的行为反应显示，在特征为短攻击潜伏期（SAL）的选择线和具有长攻击潜伏期（LAL）的选择线之间是不同的（4）。攻击性SAL小鼠比非攻击性LAL雄性对阿扑吗啡更敏感。这项研究的目的是确定对阿扑吗啡的定型反应是否受Y染色体影响的方式与影响攻击潜伏期的方式相同。为此，使用了F1互惠杂种以及同系品系（SAL.LY和LAL.SY）。同系和亲本系之间的主要区别是Y染色体的非配对部分（非PAR）。阿朴吗啡以预先选定的剂量水平（5.0 mg / kg）皮下注射，以诱导刻板行为，表现为强迫性嗅，and和舔。常染色体和非PAR Y染色体都影响对阿扑吗啡的反应。常染色体的作用与攻击性数据一致，而非PAR Y染色体的作用则不同，这表明多巴胺系统与非PAR Y染色体之间存在特定的关系。

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