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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Age-dependent anticonvulsant action of clonazepam in the N-methyl-D-aspartate model of seizures.
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Age-dependent anticonvulsant action of clonazepam in the N-methyl-D-aspartate model of seizures.

机译：氯硝西am在N-甲基-D-天冬氨酸癫痫发作模型中的年龄依赖性抗惊厥作用。

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摘要

Seizures may result from an impaired balance between excitation and inhibition. We tested whether clonazepam [a benzodiazepine that enhances GABAA inhibitory transmission (0.2 or 1.0 mg/kg, intraperitoneally [i.p.])] suppresses an age-dependent pattern of N-methyl-D-aspartate (NMDA)-induced phenomena in 7-, 12-, 18-, 25-, and 60-day-old rats (10, 40, 100, 100, and 200 mg/kg of NMDA, i.p., respectively). There were no effects of clonazepam against the NMDA-induced automatisms and emprosthotonus. In 7-day-old rats, clonazepam was proconvulsant in clonic-tonic seizures (it decreased the latency to onset of seizures, whereas it was anticonvulsant in 25-day-old rats. There was no difference between anticonvulsant effects of clonazepam and its solvent in 12- and 60-day-old rats. Both cortical and hippocampal EEG seizures was extremely poor in this model. There was no improvement of EEG recording after clonazepam. The results demonstrate that impaired excitation cannot be simply balanced by an enhanced inhibition and that the drug effects in young animals cannot be predicted from the effects in adults.
机译：兴奋和抑制之间的平衡受损可能导致癫痫发作。我们测试了氯硝西am [一种可增强GABAA抑制性传递的苯二氮卓（0.2或1.0 mg / kg，腹膜内[ip]）]是否能抑制年龄依赖性的N-甲基-D-天冬氨酸（NMDA）诱导的7- 12、18、25和60天大的大鼠（分别为ipda的10、40、100、100和200 mg / kg NMDA）。氯硝西am对NMDA引起的自动症和嗜神经性腹膜炎没有作用。在7天大的大鼠中，氯硝西am在阵挛性惊厥中是惊厥的（它降低了癫痫发作的潜伏期，而在25天大的大鼠中是抗惊厥的。氯硝西am和其溶剂的抗惊厥作用没有差异在12和60日龄的大鼠中，该模型的皮质和海马脑电图癫痫发作均极差，氯硝西am治疗后脑电图记录没有改善，结果表明不能通过增强抑制作用简单地平衡受损的兴奋性，并且不能从成年动物的作用中预测幼年动物的药物作用。

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