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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Complementary memory storage sites in mice: their development as affected by the competitive NMDA receptor antagonist, CPP.
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Complementary memory storage sites in mice: their development as affected by the competitive NMDA receptor antagonist, CPP.

机译：小鼠中的互补记忆存储位点：受竞争性NMDA受体拮抗剂CPP影响，它们的发育。

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Bitemporal injections of puromycin consistently induce amnesia of aversive maze learning in mice when administered within 3 days of training. These bitemporal puromycin injections lose their amnestic effectiveness if the latency between training and injection is extended beyond 6 days. Consistent with other evidence, we conclude that in our experimental paradigm, complementary memory storage sites normally develop in additional cerebral areas within 6 days following training. Previous experiments have indicated that the central adrenergic and cholinergic systems are critically involved in this process. We now present evidence that administration of the NMDA receptor antagonist, CPP, blocks the development of these complementary memory storage sites. As suggested by studies of long-term potentiation, NMDA receptor-dependent postsynaptic calcium appears to be essential for the development of these storage sites and indeed to trigger their development.
机译：在训练后3天内给予嘌呤霉素双时注射，可持续诱导小鼠厌恶迷宫学习失忆。如果训练和注射之间的潜伏期延长至6天以上，则这些双时相嘌呤霉素注射剂将失去记忆删除效果。与其他证据一致，我们得出结论，在我们的实验范式中，补充记忆存储位点通常在训练后6天内在其他大脑区域内发育。先前的实验表明，中央肾上腺素能和胆碱能系统至关重要地参与了这一过程。我们现在提供证据表明，NMDA受体拮抗剂CPP的给药会阻止这些互补记忆存储位点的发展。正如长期增强研究所表明的那样，依赖NMDA受体的突触后钙似乎对于这些贮藏位点的发展必不可少，并确实触发了它们的发展。

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