• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Paradoxical conditioning of the plasma copper and corticosterone responses to bacterial endotoxin.
【24h】

Paradoxical conditioning of the plasma copper and corticosterone responses to bacterial endotoxin.

机译：血浆铜和皮质酮对细菌内毒素的反应存在矛盾。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The cascade of physiologic mechanisms in response to infection, the acute phase response, is recognized as having a major role in host defense. Two such responses are an increase in plasma copper and activation of the hypothalamic-pituitary-adrenal axis, which are consistently reported to occur during bacterial infection. We aimed to determine whether the alterations in plasma copper and corticosterone were conditionable using the conditioned taste aversion paradigm. The regime involved the pairing of a novel-tasting saccharine solution (the conditioned stimulus) with lipopolysaccharide (the unconditioned stimulus). Seven days after the initial pairing of these stimuli (the test day), the saccharine solution was represented. Animals exposed to this condition displayed a significant decrease in plasma copper levels. In addition, these rats experienced a reduction in plasma corticosterone that was time dependent. Paradoxically, the conditioned response of both these variables were in a direction contraryto that reported during bacterial infection. These results suggest that some acute phase responses may condition as a rebound response, or in an opposing trend to that occurring as the initial reaction.
机译：响应感染（急性阶段反应）的生理机制的级联被认为在宿主防御中起主要作用。两种这样的反应是血浆铜的增加和下丘脑-垂体-肾上腺轴的激活，这一直被报道在细菌感染期间发生。我们旨在确定使用条件性厌恶范式是否可以调节血浆铜和皮质酮的变化。该方案包括将新品尝的糖精溶液（条件刺激）与脂多糖（非条件刺激）配对。这些刺激物首次配对后的第7天（测试日），显示了糖精溶液。暴露于这种情况的动物血浆铜水平显着下降。此外，这些大鼠的血浆皮质类固醇激素减少是时间依赖性的。矛盾的是，这两个变量的条件响应都与细菌感染期间报告的方向相反。这些结果表明，某些急性期反应可能是反弹反应，或者与最初反应相反。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号