Metabolie Engineering of Escherichia coli for Reductive Whole-cell Biotrans-formations for Production of Sugar Alcohols and Chiral Hydroxy Compounds

S.Bringer-Meyer; M.Ernst; B.Kaup; M.Muller; H.Sahm

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Metabolie Engineering of Escherichia coli for Reductive Whole-cell Biotrans-formations for Production of Sugar Alcohols and Chiral Hydroxy Compounds

机译：大肠杆菌的代谢工程，用于还原性全细胞生物转化，用于生产糖醇和手性羟基化合物

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Whole-cell biotransformation Systems for the conversion of D-fructose to D-mannitol or the reduetion of methyl aceto-acetate to methyl(R)-3-hydroxy butanoate were established in recombinant Escherichia coli strains.Strains construeted contained a recombinant reduction-/oxidation cycle,com-prising NAD-dependent formate dehydrogenase from Mycobacterium vaccae N10(FDH)generating NADH,which was used either by mannitol dehydrogenase from Leuco-nostoc pseudomesenteroid.es ATCC 12291(MDH),or by(R)-speeifie,NADP-preferring alcohol dehydrogenase from Lactobacillus brevis for the respective reduetions.Further-more,for the uptake of D-fructose a glucose facilitator of Zymomonas mobilis(GLF)was additionally expressed in the recombinant D-mannitol producing E.coli strain.

机译：在重组大肠杆菌菌株中建立了将D-果糖转化为D-甘露糖醇或将乙酰乙酸甲酯还原为（R）-3-羟基丁酸甲酯的全细胞生物转化系统，该菌株包含重组还原-/氧化循环，包括由牛分枝杆菌N10（FDH）产生NADH的NAD依赖的甲酸脱氢酶，该酶可用于Leuco-nostoc假性肠系膜的甘露醇脱氢酶ATCC 12291（MDH）或speeifie，NADP短乳杆菌优选乙醇脱氢酶用于相应的还原反应。此外，为了吸收D-果糖，在重组产生D-甘露醇的大肠杆菌菌株中另外表达了运动发酵单胞菌（GLF）的葡萄糖促进剂。

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《Chemie-Ingenieur-Technik: Verfahrenstechnik Technische Chemie Apparatewesen Biotechnologie》 |2004年第9期|共1页
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S.Bringer-Meyer; M.Ernst; B.Kaup; M.Muller; H.Sahm;
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1. Metabolie Engineering of Escherichia coli for Reductive Whole-cell Biotrans-formations for Production of Sugar Alcohols and Chiral Hydroxy Compounds [J] . S.Bringer-Meyer, M.Ernst, B.Kaup, Chemie-Ingenieur-Technik: Verfahrenstechnik Technische Chemie Apparatewesen Biotechnologie . 2004,第9期

机译：大肠杆菌的代谢工程，用于还原性全细胞生物转化，用于生产糖醇和手性羟基化合物
2. Whole-cell biotransformation systems for reduction of prochiral carbonyl compounds to chiral alcohol in Escherichia coli [J] . Bingjuan Li, Yuxia Li, Dongmei Bai, Scientific reports. . 2014,第1期

机译：用于在大肠杆菌中将前手性羰基化合物还原为手性醇的全细胞生物转化系统
3. Engineering Escherichia coli for the production of terpene mixture enriched in caryophyllene and caryophyllene alcohol as potential aviation fuel compounds [J] . Weihua Wu, Fang Liu, Ryan W. Davis Metabolic Engineering Communications . 2018,第1期

机译：工程大肠杆菌，用于生产富含作为潜在航空燃料化合物的石竹烯和石竹烯醇的萜烯混合物
4. Production of hydroxy-fatty acids and alkanediols by Escherichia coli cells producing fungal cytochrome P450foxy [C] . Kitazume T., Yamazaki Y., Idate A. Takaya N. International Conference on Cytochrome P450 . 2009

机译：通过大肠杆菌细胞生产羟基 - 脂肪酸和烷二醇，产生真菌细胞色素P450FOXY
5. Metabolic Engineering and Directed Evolution of Perillyl Alcohol Biosynthetic Pathway in Escherichia coli to Produce Compounds with Anti-cancer Activity Against Breast cancer cell lines. [D] . Gupta, Shweta. 2013

机译：代谢工程和大肠杆菌中紫苏氨醇生物合成途径的定向进化，以产生具有针对乳腺癌细胞系的抗癌活性的化合物。
6. Whole-cell biotransformation systems for reduction of prochiral carbonyl compounds to chiral alcohol in Escherichia coli [O] . Bingjuan Li, Yuxia Li, Dongmei Bai, -1

机译：用于在大肠杆菌中将前手性羰基化合物还原为手性醇的全细胞生物转化系统
7. Engineering a pyridoxal 5’-phosphate supply for cadaverine production by using Escherichia coli whole-cell biocatalysis [O] . Weichao Ma, Weijia Cao, Bowen Zhang, 2015

机译：通过使用大肠杆菌全细胞生物分析来工程用大肠杆菌生产的卤素5'-磷酸盐供应

Metabolie Engineering of Escherichia coli for Reductive Whole-cell Biotrans-formations for Production of Sugar Alcohols and Chiral Hydroxy Compounds

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