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首页> 外文期刊>Pharmacology and Toxicology: An International Journal >IgE-mediated asthma and rhinitis I: a role of allergen exposure?
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IgE-mediated asthma and rhinitis I: a role of allergen exposure?

机译：IgE介导的哮喘和鼻炎I：过敏原暴露的作用？

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摘要

Exposures to airborne protein antigens, aeroallergens, may cause sensitization with production of Th2-dependent antibodies, including IgE. The IgE antibodies and associated cellular responses are responsible for the allergic airway diseases, allergic rhinitis and allergic asthma, which are increasing in societies with Western life style. Aeroallergens may have different potential to sensitize exposed subjects. Thus, there are only a limited number of important groups of aeroallergens, which are those from house dust mites, cockroaches, pets, pollens, and moulds. Allergy follows to a certain extent the pharmacological/toxicological paradigm of dose-response relationship. Unlike effects of pharmacologically and toxicologically active substances, allergens elicit their adverse effects in a two-stage process. In the first stage the immunologically naive individual is sensitized to the allergen. In the second stage renewed exposure to the allergen elicits the disease response. Also, high concentrations of aeroallergens may induce immunological tolerance. The scientific literature suggests that many environmental factors contribute to the increase in sensitization and development of airway allergies. Nevertheless, the dose-response relationships apply (within certain limits) both to the sensitization itself and to the exacerbation of the diseases. This suggest that exposure reduction may be one of the methods for reduction of risk, in relation to control of the allergic airway diseases.
机译：暴露于空气传播的蛋白抗原，空气变应原可能会引起Th2依赖性抗体（包括IgE）的致敏。 IgE抗体和相关的细胞反应是导致过敏性气道疾病，过敏性鼻炎和过敏性哮喘的原因，在西方生活方式日益增多的社会中，这种疾病正在增加。空气变应原可能具有不同的潜力来致敏暴露的受试者。因此，仅有少量重要的气敏性过敏原，它们是来自屋尘螨，蟑螂，宠物，花粉和霉菌的气致敏过敏原。过敏在一定程度上遵循剂量-反应关系的药理/毒理学范式。与药理学和毒理学活性物质的作用不同，过敏原在两个阶段的过程中引发不良反应。在第一阶段中，免疫原初的个体对过敏原敏感。在第二阶段，重新暴露于过敏原会引发疾病反应。同样，高浓度的空气过敏原可能会诱导免疫耐受。科学文献表明，许多环境因素导致气道过敏的敏感性增加和发展。然而，剂量-反应关系（在一定范围内）适用于致敏作用本身和疾病的恶化。这表明与控制过敏性气道疾病有关，减少接触可能是降低风险的方法之一。

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