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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Chronic morphine consumption decreases wheel running and wheel running-reinforced behavior in rats.
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Chronic morphine consumption decreases wheel running and wheel running-reinforced behavior in rats.

机译：慢性吗啡消耗会降低大鼠的车轮行驶和车轮行驶增强行为。

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摘要

The purpose of this experiment was to evaluate the effects of morphine self-administration on wheel running and wheel running-reinforced lever pressing in rats. The home cage was equipped with a bottle that contained either water, a saccharin-flavored 0.5-mg/ml morphine solution, or saccharin (0.25%). The bottle was available for either 1 or 3 h. The bottle was then removed, and 20-22 h after removal, the rats were moved to an operant chamber in which lever presses earned 15 s access to a running wheel (according to a variable interval (VI) 40-s schedule). The morphine condition was in effect for 69 days, and consumption gradually increased to a level of 67 mg/kg/day. During the morphine condition, wheel running and lever pressing decreased. Following the removal of morphine, (so that the home-cage bottles provided a 0.25% saccharin solution), the two instrumental behaviors increased to the pre-morphine (water) levels. However, the increases were not immediate, and in the first post-morphine session, lever pressing and wheel turning remained at the depressed morphine level. The post-morphine increase in lever pressing was substantially larger than the increase in wheel running. The results support the hypothesis that chronic opiate consumption reduces the frequency of some nondrug-related behaviors, and that this, in turn, increases preference for the opiate.
机译：本实验的目的是评估吗啡自我给药对大鼠车轮行驶和车轮行驶增强的杠杆压迫的影响。家用笼子装有一个装有水，糖精味的0.5 mg / ml吗啡溶液或糖精（0.25％）的瓶子。瓶子可用1或3小时。然后将瓶子取下，取下瓶子后20-22小时，将大鼠移至手术室，在其中的杠杆压力机获得15 s的行走轮访问时间（按照可变间隔（VI）40-s的时间表）。吗啡条件持续了69天，消耗量逐渐增加到67 mg / kg / day。在吗啡条件下，车轮行驶和压杆下降。除去吗啡后（使家用笼装瓶提供了0.25％的糖精溶液），两种仪器的性能均增加到吗啡前（水）水平。但是，这种增加不是立即的，在吗啡后的第一个疗程中，操纵杆的按压和车轮转动仍保持在吗啡水平降低的状态。吗啡后操纵杆压力的增加远大于车轮行驶的增加。该结果支持以下假设：慢性鸦片消费会减少某些与毒品无关的行为的发生频率，进而增加对鸦片的偏好。

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