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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Further investigation of allopurinol effects on MPTP-induced oxidative stress in the striatum and brain stem of the rat.
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Further investigation of allopurinol effects on MPTP-induced oxidative stress in the striatum and brain stem of the rat.

机译：进一步研究别嘌呤醇对大鼠纹状体和脑干中MPTP诱导的氧化应激的影响。

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Levels of uric acid, xanthine, hypoxanthine, ascorbic acid (AA), dehydroascorbic acid (DHAA), glutathione (GSH), noradrenaline (NA), dopamine (DA), dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), 5-hydroxytryptamine (5-HT), 5-hydroxyindoleacetic acid (5-HIAA) 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridinium ion (MPP+) were determined in the striatum and/or in the brain stem of 3-month-old male Wistar rats given allopurinol (300 mg/kg day by gavage) for 3 days before a single MPTP 35 mg/kg dose IP. Allopurinol alone decreased uric acid and increased xanthine levels both in the striatum and in the brain stem; moreover, allopurinol decreased striatal DOPAC + HVA/DA ratio and increased 5-HIAA/5HT ratio in the brainstem. Allopurinol affected neither regional MPTP nor MPP+ disposition. Allopurinol potentiated the MPTP-induced decrease in the DOPAC+HVA/DA ratio and increase in striatal AA oxidation; in addition, allopurinol antagonised the MPTP-induced: (i) increase in uric acid levels; (ii) decrease in NA levels in both regions, in DA levels, and in the 5-HIAA/5-HT ratio in the brain stem: (iii) increase in AA oxidation in the brain stem. In conclusion, the MPP(+)-induced oxidative stress mediated by xanthine oxidase seems to be involved in DA depletion in the brainstem and in NA depletion in both regions; moreover, striatal uric acid may have an active role in the neuronal antioxidant pool.
机译：尿酸，黄嘌呤，次黄嘌呤，抗坏血酸（AA），脱氢抗坏血酸（DHAA），谷胱甘肽（GSH），去甲肾上腺素（NA），多巴胺（DA），二羟苯乙酸（DOPAC），高香草酸（HVA），5-测定了羟色胺（5-HT），5-羟吲哚乙酸（5-HIAA）1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）和1-甲基-4-苯基吡啶鎓离子（MPP +）在给3个月大的雄性Wistar大鼠的纹状体和/或脑干中注射3mg / kg剂量的IPTP的别嘌呤醇（每天300 mg / kg灌胃）3天。单独的别嘌醇降低纹状体和脑干中的尿酸并增加黄嘌呤水平。此外，别嘌呤醇降低了脑干的纹状体DOPAC + HVA / DA比，并提高了5-HIAA / 5HT比。别嘌呤醇既不影响区域性MPTP也不影响MPP +的处置。别嘌醇增强了MPTP诱导的DOPAC + HVA / DA比值的降低和纹状体AA氧化的增加;另外，别嘌呤醇拮抗MPTP诱导的：（i）尿酸水平升高; （ii）脑干中两个区域的NA水平，DA水平和5-HIAA / 5-HT比率均下降：（iii）脑干中AA氧化增加。总之，黄嘌呤氧化酶介导的MPP（+）诱导的氧化应激似乎与脑干的DA消耗和两个区域的NA消耗有关。此外，纹状体尿酸可能在神经元抗氧化剂池中发挥积极作用。

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