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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Lateral parabrachial lesions impair taste aversion learning induced by blood-borne visceral stimuli.
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Lateral parabrachial lesions impair taste aversion learning induced by blood-borne visceral stimuli.

机译：外侧臂旁损伤损害了血源性内脏刺激引起的味觉厌恶学习。

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摘要

The lateral parabrachial area (LPB), main relay from the area postrema (AP), plays a role in processing visceral information and is thus of potential importance in taste aversion learning (TAL). This study used a lesion approach to address whether LPB functional relevance depends upon the features of toxins that serves as visceral stimuli in TAL. In addition, we explored whether LPB involvement in TAL is restricted to those toxic events detected by the AP or whether it has a more general role. Results showed that LPB-lesioned animals were disrupted in acquiring a TAL induced by blood-borne AP-dependent aversive stimuli (intraperitoneal methylscopolamine) and by AP-independent stimulus (intraperitoneal ethanol), but still, clearly developed strong aversions when intragastric hypertonic sodium chloride, a vagally processed aversive stimulus, served as the aversive stimulus. These findings suggest that the LPB plays a critical role in TAL induced by blood-borne toxins, such as methylscopolamine or ethanol, but is not necessary for vagally mediated stimulus, such as sodium chloride. The present results are discussed in the context of the hypothesis holding separable and independent neural systems underlying TAL.
机译：臂外侧臂旁区域（LPB）是来自后区域（AP）的主要中继器，在处理内脏信息中发挥作用，因此在味觉学习（TAL）中具有潜在的重要性。这项研究使用病变方法来解决LPB功能相关性是否取决于在TAL中作为内脏刺激物的毒素的特征。此外，我们探讨了LPB是否参与TAL仅限于AP检测到的那些毒性事件或它是否具有更广泛的作用。结果表明，LPB病变的动物在获取血源性AP依赖性厌恶刺激物（腹膜内甲基东pol碱）和非AP依赖性刺激物（腹膜内乙醇）诱导的TAL时受到干扰，但当胃内高渗氯化钠明显产生强烈的厌恶感时，经过阴道处理的厌恶刺激物，作为厌恶刺激物。这些发现表明，LPB在由血源性毒素（如甲基sco碱或乙醇）诱导的TAL中起关键作用，但对于阴道介导的刺激（如氯化钠）则不是必需的。在持有TAL基础的可分离和独立神经系统的假设的背景下讨论了当前结果。

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