• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Central 5-HT(4) receptors and dopamine-dependent motor behaviors: searching for a functional role.
【24h】

Central 5-HT(4) receptors and dopamine-dependent motor behaviors: searching for a functional role.

机译：中央5-HT（4）受体和多巴胺依赖的运动行为：寻找功能的作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In this study, we evaluated the role of central 5-HT(4) receptors in the control of motor behaviors related to change of nigrostriatal dopamine (DA) transmission, namely, stereotyped behavior and catalepsy in rats. Indeed, given that 5-HT(4) receptors indirectly modulate nigrostriatal DA neuron activity, we hypothesized that these receptors would regulate nigrostriatal DA transmission in the basal ganglia, and consequently, associated motor responses. Stereotypy was induced either by an acute administration of apomorphine (0.3 and 1.5 mg/kg sc), or by a single morphine administration (15 mg/kg sc) in chronically morphine-treated (15 mg/kg sc, twice daily for 10 days) rats. Catalepsy was induced by the typical neuroleptic haloperidol (HAL; 1 mg/kg sc). The selective 5-HT(4) antagonist, GR 125487 (1 mg/kg ip), modified neither apomorphine- nor morphine-induced stereotypy. HAL-induced catalepsy, while reduced by the systemic administration of the 5-HT(1A) agonist 8-OH-DPAT (0.1 mg/kg sc), was insensitive to GR 125487, systemically (1, 3, 10 mg/kg ip) or locally (20 and 40 nmol/20 microl) administered into the third ventricle. Also, HAL-induced catalepsy was not affected by the selective 5-HT(4) antagonist GR 113808 (3 mg/kg ip). The obtained results indicate that 5-HT(4) receptor antagonism does not modulate motor behaviors related to change of striatal DA transmission.
机译：在这项研究中，我们评估了中枢5-HT（4）受体在控制与黑质纹状体多巴胺（DA）传递变化有关的运动行为中的作用，即大鼠的定型行为和僵直。确实，鉴于5-HT（4）受体间接调节黑纹状体DA神经元的活性，我们假设这些受体将调节黑质纹状体DA在基底神经节中的传递，并因此调节相关的运动反应。在急性吗啡治疗（15 mg / kg sc，每天两次，连续10天）中，通过急性给予阿扑吗啡（0.3和1.5 mg / kg sc）或通过单次吗啡给药（15 mg / kg sc）诱导定型。 ）大鼠。典型的抗精神病药物氟哌啶醇（HAL; 1 mg / kg sc）引起僵直。选择性5-HT（4）拮抗剂GR 125487（1 mg / kg ip ip）不会改变阿扑吗啡或吗啡引起的刻板印象。 HAL诱导的僵直症，尽管通过全身给药5-HT（1A）激动剂8-OH-DPAT（0.1 mg / kg sc）减少，但对GR 125487全身性不敏感（1、3、10 mg / kg ip ）或局部（20和40 nmol / 20微升）施用于第三脑室。此外，HAL诱导的僵直症不受选择性5-HT（4）拮抗剂GR 113808（3 mg / kg ip）的影响。获得的结果表明，5-HT（4）受体拮抗作用不会调节与纹状体DA传输变化有关的运动行为。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号