• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Interactions between the CB1 receptor agonist Delta(9)-THC and the CB1 receptor antagonist SR-141716 in rats. Open-field revisited.
【24h】

Interactions between the CB1 receptor agonist Delta(9)-THC and the CB1 receptor antagonist SR-141716 in rats. Open-field revisited.

机译：CB1受体激动剂Delta（9）-THC与CB1受体拮抗剂SR-141716之间的相互作用。再次考虑开放领域。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

This study examined the effects of Delta(9)-tetrahydrocannabinol (Delta(9)-THC) and the CB1 antagonist SR-141716 on open-field behaviors in male Sprague-Dawley rats. Animals were examined after administration of Delta(9)-THC alone (dose range: 0.3-5.6 mg/kg), SR-141716 alone (dose range: 1-5.6 mg/kg) and the two drugs in combination; injections were given intraperitoneally 30 min prior to testing. There was a dose-related suppression of ambulation (horizontal activity) and rearing (vertical activity) after Delta(9)-THC administration. Co-administration of SR-141716 counteracted this suppression; however, antagonism was only partial for rearing. Interestingly, 1 mg/kg SR-141716 was as effective as 3 and 5.6 mg/kg SR-141716 in this antagonist action. Increasing doses of Delta(9)-THC produced an increase in circling behavior; latency to leave the starting area in the center of the field was significantly elevated by 5.6 mg/kg Delta(9)-THC. Those effects were completely blocked by SR-141716. Grooming and scratching showed a dose-related increase following administration of SR-141716 (1-5.6 mg/kg), which were only partially blocked by co-administration of Delta(9)-THC (3 and 5.6 mg/kg). When given alone, only the highest dose of SR-141716 (5.6 mg/kg) depressed ambulation; rearing and latency were not significantly changed, and circling was absent. Differences in the number of vocalizations, urination and defecation generally did not differ clearly among the treatment conditions. These results may show that SR-141716 is acting as (i) an inverse agonist and/or (ii) that the endogenous cannabinoid system is tonically active under certain conditions.
机译：这项研究检查了Delta（9）-四氢大麻酚（Delta（9）-THC）和CB1拮抗剂SR-141716对雄性Sprague-Dawley大鼠开放视野行为的影响。单独给予Delta（9）-THC（剂量范围：0.3-5.6 mg / kg），单独给予SR-141716（剂量范围：1-5.6 mg / kg）和两种药物组合后，检查动物。在测试前30分钟腹膜内注射。 Delta（9）-THC给药后，有一个与剂量有关的活动抑制（水平活动）和饲养（垂直活动）抑制。 SR-141716的共同管理抵消了这种抑制。然而，拮抗只是部分原因。有趣的是，在这种拮抗作用中，1 mg / kg SR-141716与3和5.6 mg / kg SR-141716一样有效。逐渐增加剂量的Delta（9）-THC导致了盘旋行为的增加。离开场中心起始区域的潜伏期显着提高了5.6 mg / kg Delta（9）-THC。这些效果被SR-141716完全阻止。施用SR-141716（1-5.6 mg / kg）后，修饰和刮擦显示出剂量相关的增加，但仅通过Delta（9）-THC（3和5.6 mg / kg）的共同施用而部分阻止。单独服用时，仅最高剂量的SR-141716（5.6 mg / kg）抑制了下肢活动;饲养和潜伏期没有显着变化，并且没有圈养。在不同的治疗条件下，发声，排尿和排便次数的差异通常没有明显差异。这些结果可能表明SR-141716充当（i）反向激动剂和/或（ii）内源性大麻素系统在某些条件下具有音调活性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号