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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Tolerance to the disruptive effects of Delta(9)-THC on learning in rats.
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Tolerance to the disruptive effects of Delta(9)-THC on learning in rats.

机译：耐受Delta（9）-THC对大鼠学习的破坏作用。

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摘要

Tolerance to the effects of the cannabinoid agonist Delta(9)-tetrahydrocannabinol (Delta(9)-THC) was characterized in rats responding under a multiple schedule of repeated acquisition and performance. During the acquisition component, subjects acquired a different three-response sequence each session, whereas in the performance component the sequence was the same each session. Responding was maintained under a second-order fixed-ratio 2 (FR2) schedule of food reinforcement. Acute doses of Delta(9)-THC (1-10 mg/kg) decreased rate and accuracy in both components, whereas doses of the cannabinoid (CB1) receptor antagonist N-(piperidin-1-yn-)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H- pyrazole-3-carboxamide hydrochloride (SR141716A; 0.32 and 1 mg/kg) were ineffective. While 5.6 mg/kg of Delta(9)-THC disrupted responding when administered acutely, tolerance to the rate-decreasing and error-increasing effects of this dose developed in both components after daily administration. When 1 mg/kg of SR141716A was substituted for Delta(9)-THC during chronic administration, this previously ineffective dose selectively increased within-session errors in the acquisition component of the multiple schedule. During the postchronic phase, subjects were generally less sensitive to the disruptive effects of Delta(9)-THC. In summary, these data demonstrated that tolerance to Delta(9)-THC developed across two different behavioral tasks and that learning was generally more sensitive than performance to the effects of SR141716A during chronic treatment with Delta(9)-THC.
机译：耐受对大麻素激动剂Delta（9）-四氢大麻酚（Delta（9）-THC）的影响，在多次重复获取和表现的多个时间表中做出反应的大鼠中进行了表征。在习得部分中，受试者在每个会话中获取了一个不同的三响应序列，而在表演要素中，每个会话中的序列相同。维持食物补充的二阶固定比率2（FR2）时间表。急性剂量的Delta（9）-四氢大麻酚（1-10 mg / kg）降低了这两种成分的使用率和准确性，而大麻素（CB1）受体拮抗剂N-（piperidin-1-yn-）-5-（4 -氯苯基）-1-（2,4-二氯苯基）-4-甲基-1H-吡唑-3-羧酰胺盐酸盐（SR141716A; 0.32和1 mg / kg）无效。虽然5.6 mg / kg的Delta（9）-THC急性给药会中断反应，但是在每日给药后，两种成分均对这种剂量的速率降低和误差增加效应产生了耐受性。在慢性给药过程中，当用1 mg / kg的SR141716A代替Delta（9）-THC时，此先前无效的剂量选择性地增加了多疗程的采集部分的疗程内误差。在慢性后阶段，受试者通常对Delta（9）-THC的破坏作用不那么敏感。总而言之，这些数据表明，在两种不同的行为任务中对Delta（9）-THC的耐受性增强，并且在对Delta（9）-THC进行慢性治疗期间，学习通常比对SR141716A的效果更敏感。

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