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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Fixed ratio discrimination training increases in vivo striatal dopamine in neonatal 6-OHDA-lesioned rats.
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Fixed ratio discrimination training increases in vivo striatal dopamine in neonatal 6-OHDA-lesioned rats.

机译：固定比例歧视训练增加了新生的6-OHDA损伤大鼠体内的纹状体多巴胺。

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摘要

Massed training in the conditional discrimination task, the fixed ratio discrimination (FRD) task led to elevated extracellular dopamine (DA) concentrations in the neonatal 6-hydroxydopamine (6-OHDA)-treated rat, a model of Lesch-Nyhan disease (LND). Rats neonatally treated with 6-OHDA or its vehicle were, as adults, implanted with microdialysis probes and assessed for basal pretraining concentrations of DA and its major metabolites. Subsequently, microdialysis samples were collected each day following three separate FRD training periods (trained group) or three separate periods of noncontingent food presentations (untrained group). The present study found that there were significant increases in extracellular DA in the caudate-putamen from basal pretraining concentrations in the repeated sample collections of trained 6-OHDA-lesioned animals but not in the samples of untrained 6-OHDA-lesioned animals. Consistent with previous studies [Brain Res. 508 (1990) 30.], there was an increase in the extracellular concentrations as compared to tissue concentrations of DA and 3,4-dihydroxyphenylacetic acid (DOPAC). Similar to our previous studies with long-term FRD training [Pharmacol. Biochem. Behav. 51 (1995) 861; Brain Res. 713 (1996) 246.], there was also an indication of an increase in cortical and striatal tissue concentration of DA in the trained 6-OHDA-lesioned animals as compared to the untrained 6-OHDA-lesioned animals. The elevations in striatal DA concentrations following operant performance in the present study illustrate how operant procedures of the behavior therapy used with individuals with LND and other mental retardation syndromes may interact with the modulation of dopaminergic function by the pharmaceutical application of DA antagonists to suppress aberrant behaviors.
机译：在条件歧视任务中进行大规模培训，固定比率歧视（FRD）任务导致新生的6-羟基多巴胺（6-OHDA）治疗的大鼠（Lesch-Nyhan病（LND）的模型）中的细胞外多巴胺（DA）浓度升高。成年后，将接受6-OHDA或其媒介物新生儿治疗的大鼠植入微透析探针，并对其DA及其主要代谢产物的基础预训练浓度进行评估。随后，在三个单独的FRD训练期（训练组）或三个单独的非偶然性食物展示（未训练组）之后，每天收集微透析样品。本研究发现，经过训练的6-OHDA损伤动物的重复样本集合中，基础训练前浓度使尾状-丘脑中的胞外DA显着增加，但未训练的6-OHDA损伤动物的样本中则没有。与以前的研究一致[Brain Res。 508（1990）30。]，与DA和3，4-二羟基苯基乙酸（DOPAC）的组织浓度相比，细胞外浓度增加。类似于我们先前对FRD进行长期培训的研究[Pharmacol。生化。行为。 51（1995）861;脑水库。 713（1996）246.]，还表明与未经训练的6-OHDA损伤的动物相比，经过训练的6-OHDA损伤的动物的皮质和纹状体组织中DA的浓度增加。在本研究中，随着手术表现的增加，纹状体DA浓度升高说明了LND和其他智力低下综合征患者的行为疗法的手术程序如何通过DA拮抗剂的药物应用抑制异常行为而与多巴胺能功能的调节相互作用。 。

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