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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effect of a single maternal separation at different pup ages on the corticosterone stress response in adult and aged rats.
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Effect of a single maternal separation at different pup ages on the corticosterone stress response in adult and aged rats.

机译：母体分离在不同幼龄时对成年和成年大鼠皮质酮应激反应的影响。

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摘要

Postnatal days (PNDs) 4-14 constitute the stress hyporesponsive period (SHRP) of the rat's pituitary-adrenal axis. The impact of manipulation of the pup-dam relationship during the SHRP on neuroendocrine and behavioural function has been the subject of considerable investigation. A single period of 24-h separation of the litter from the dam (maternal separation, MS) during the SHRP increases pup pituitary-adrenal activity and attenuates the SHRP. The MS manipulation also allows for the age-specific analysis of the chronic effects of early-life stress. Here we report on the effects of MS performed at the beginning of (PND 4), or about midway into (PND 9), or after (PND 18) the SHRP, on basal and stress-related blood corticosterone (CORT) titers in mature (month 5) and old (month 20) adult males. MS at PND 4, 9, or 18 did not affect basal CORT plasma titers. MS at each of these ontogenetic stages led to a similar and significant increase in the CORT response to restraint in adults but not in old adults. Therefore, whereas MS exerts a chronic impact on stress-related pituitary-adrenal activity in adult male rats, the effect of this postnatal experience does not depend upon the ontogenetic/SHRP status of the pup, and nor does it persist into senescence.
机译：产后天数（PNDs）4-14构成了大鼠垂体-肾上腺轴的应激低反应期（SHRP）。在SHRP期间操纵小坝关系对神经内分泌和行为功能的影响已成为大量研究的主题。在SHRP期间，产仔与大坝的24小时分离（母体分离，MS）是一个单一的时期，它会增加幼仔垂体-肾上腺的活动并减弱SHRP。 MS操作还允许对早期生活压力的慢性影响进行针对年龄的分析。在这里，我们报告了SHRP在（PND 4）开始时或进入（PND 9）中途，或在（PND 18）之后或之后（PND 18）进行的MS对成熟期基础和应激相关的血液皮质酮（CORT）滴度的影响（第5个月）和老年（第20个月）成年男性。 PND 4、9或18的MS不会影响基础CORT血浆滴度。在这些个体发育阶段的每个阶段，MS导致成年人对约束的CORT反应相似且显着增加，而成年人则没有。因此，尽管MS对成年雄性大鼠的应激相关垂体-肾上腺活动产生了慢性影响，但这种产后经历的影响并不取决于幼犬的个体发育/ SHRP状态，也不会持续到衰老。

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