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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Electrical stimulation of the dorsal and median raphe nuclei increases extracellular noradrenaline in rat hippocampus: Evidence for a 5-HT-independent mechanism.
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Electrical stimulation of the dorsal and median raphe nuclei increases extracellular noradrenaline in rat hippocampus: Evidence for a 5-HT-independent mechanism.

机译：背和正中缝核的电刺激会增加大鼠海马中的细胞外去甲肾上腺素：5-HT依赖性机制的证据。

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Recent studies have used raphe stimulation combined with in vivo measurements of extracellular dopamine to investigate interactions between the 5-hydroxytryptamine (5-HT) and dopamine systems. Here we have tested whether the same approach can be used to investigate interactions between the 5-HT and noradrenaline systems. Electrical stimulation of the dorsal raphe nucleus (DRN) or median raphe nucleus (MRN) was performed in anaesthetised rats implanted with microdialysis probes in the hippocampus and locus coeruleus (LC). DRN stimulation (3, 5 and 10 Hz) evoked a frequency-dependent increase in extracellular noradrenaline in the hippocampus. MRN stimulation had a similar effect. Both DRN and MRN stimulations enhanced extracellular 5-HT levels in the LC and previous studies have demonstrated that extracellular 5-HT also increases in the hippocampus. However, the increase in hippocampal noradrenaline evoked by DRN stimulation was not altered by 5-HT neuronal lesions, which reduced 5-HT metabolite levels by 90%. In conclusion, electrical stimulation of the midbrain raphe increases extracellular noradrenaline in the hippocampus, however, experiments in 5-HT-lesioned animals suggest that this response is not mediated by 5-HT. Although raphe stimulation may be useful to investigate interactions between 5-HT and dopamine, our data indicate that the same approach may not be feasible for 5-HT and noradrenaline.
机译：最近的研究已经使用了裂变刺激结合体内多巴胺的体内测量来研究5-羟色胺（5-HT）与多巴胺系统之间的相互作用。在这里，我们测试了是否可以使用相同的方法来研究5-HT和去甲肾上腺素系统之间的相互作用。在麻醉的大鼠中植入了海马和蓝藻轨迹（LC）的麻醉大鼠中，对背缝核（DRN）或正中缝核（MRN）进行电刺激。 DRN刺激（3、5和10 Hz）引起海马中细胞外去甲肾上腺素的频率依赖性增加。 MRN刺激具有类似的作用。 DRN和MRN刺激均增强了LC中细胞外5-HT的水平，以前的研究表明，细胞外5-HT在海马中也增加。然而，DRN刺激引起的海马去甲肾上腺素增加并未被5-HT神经元病变所改变，后者使5-HT代谢产物水平降低了90％。总之，对中脑缝隙的电刺激会增加海马中的细胞外去甲肾上腺素，但是，对5-HT损伤的动物进行的实验表明，这种反应不是由5-HT介导的。尽管缝线刺激可能有助于研究5-HT和多巴胺之间的相互作用，但我们的数据表明，对于5-HT和去甲肾上腺素而言，相同的方法可能不可行。

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