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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Peripheral benzodiazepine receptors reflect trait (early handling) but not state (avoidance learning).
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Peripheral benzodiazepine receptors reflect trait (early handling) but not state (avoidance learning).

机译：周围的苯并二氮杂receptor受体反映特征（早期处理）但不反映状态（避免学习）。

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摘要

Behavioral animal paradigms and experimental neuroendocrinological and neurochemical studies have shown that early environmental manipulations have profound effects on the late response to stress. The aim of the present study was to investigate the interactive effects of environmental manipulation (early handling) and experimentally induced behavioral differences on the peripheral benzodiazepine receptor (PBR) system, which is known to be involved in the response to stressors. Adult early-handled (EH) and nonhandled (NH; control) Wistar rats were placed in a two-way active avoidance/latent inhibition (LI) paradigm, and PBR densities in the adrenal glands, kidneys, and gonads were assessed. In line with previous studies, overall avoidance learning improved in the EH group, and LI was disrupted in the NH group (primarily in males). PBR densities were up-regulated in EH subjects, and more so in females than males. However, PBR densities did not correlate with any of the behavioral measures. These findings strengthen the hypothesis that differences in PBR densities between EH and NH rats are a reflection of trait rather than state, and they suggest that the PBR system is characterized by a highly stressor-specific response.
机译：行为动物范例以及实验性神经内分泌和神经化学研究表明，早期的环境操作对后期对压力的反应具有深远的影响。本研究的目的是研究环境操纵（早期操纵）和实验性行为差异对周围苯并二氮杂receptor受体（PBR）系统的交互作用，已知该物质参与了对应激源的反应。将成年的早期处理（EH）和未处理的（NH;对照）Wistar大鼠置于双向主动回避/潜在抑制（LI）模式中，并评估肾上腺，肾脏和性腺中的PBR密度。与以前的研究一致，EH组的整体回避学习得到改善，而NH组的LI受到破坏（主要是男性）。 EH受试者的PBR密度上调，女性比男性更高。但是，PBR密度与任何行为指标均不相关。这些发现加强了这样的假设，即EH和NH大鼠之间PBR密度的差异是性状而非状态的反映，它们表明PBR系统的特征是高度应激源特异性反应。

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