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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >The nucleus accumbens as a site of action for rewarding properties of testosterone and its 5alpha-reduced metabolites.
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The nucleus accumbens as a site of action for rewarding properties of testosterone and its 5alpha-reduced metabolites.

机译：伏隔核是奖励睾丸激素及其5α还原代谢产物特性的作用位点。

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摘要

Testosterone (T)'s positive hedonic effects may be mediated by actions of its metabolites, dihydrotestosterone (DHT) or 3alpha-androstanediol (3alpha-diol), in the nucleus accumbens (NA). In Experiment 1, adult, intact, male rats were systemically administered 1 mg of T, DHT, 3alpha-diol or vehicle, at different time points to examine concentrations of androgens in the NA. Rats administered 3alpha-diol had significantly increased concentrations of 3alpha-diol in the region of the brain encompassing the NA. These data are consistent with previous data from our laboratory demonstrating that 3alpha-diol elicits a conditioned place preference (CPP) more effectively than either T or DHT, when administered systemically. In Experiment 2, rats received implants of T, DHT or 3alpha-diol to the NA immediately prior to placement in the CPP apparatus on conditioning days. Implants of T, DHT or 3alpha-diol, but not vehicle, significantly increased time spent on the non-preferred side of the chamber on the test day.This effect was only produced by androgenic stimulation of the shell of the NA and not the core of the NA. Thus, androgen regimens we have previously found to enhance CPP produced the greatest increases in 3alpha-diol concentrations in the NA region and direct implants of T, DHT or 3alpha-diol to the shell, but not the core, of the NA enhanced CPP. These data are consistent with the hypothesis that the hedonic effects of T may be due to actions of its metabolites in the NA.
机译：睾丸激素（T）的正享乐效应可能是由伏隔核（NA）中其代谢产物二氢睾丸激素（DHT）或3α-雄甾烷二醇（3alpha-diol）的作用介导的。在实验1中，在不同的时间点对成年的成年雄性大鼠进行1 mg的T，DHT，3alpha-二醇或赋形剂全身给药，以检查其NA中雄激素的浓度。服用3α-二醇的大鼠在包含NA的大脑区域中3α-二醇的浓度显着增加。这些数据与我们实验室先前的数据一致，证明当全身给药时3α-二醇比T或DHT更有效地引发条件性位置偏爱（CPP）。在实验2中，大鼠在条件日立即放置在CPP装置中之前，立即向NA植入了T，DHT或3α-二醇。在试验当天，植入T，DHT或3α-二醇而非媒介物会显着增加在试验室非首选侧花费的时间，这种作用仅是由雄激素刺激NA的壳而不是核心引起的NA的。因此，我们先前发现增强CPP的雄激素方案在NA区域产生了3α-二醇浓度的最大增加，并且将T，DHT或3α-二醇直接植入NA增强CPP的壳而不是核。这些数据与T的享乐效应可能是由于其NA中代谢产物的作用这一假设相一致的。

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