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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Cocaine and caffeine: conditioned place preference, locomotor activity, and additivity.
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Cocaine and caffeine: conditioned place preference, locomotor activity, and additivity.

机译：可卡因和咖啡因：条件性位置偏爱，运动活动和可加性。

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摘要

Conditioned place preference (CPP) was employed to clarify the reinforcing and locomotor stimulating effects of several doses of cocaine and caffeine (0.32, 1.0, 3.2, 5.6, and 10.0 mg/kg) and to explore the possibility of additive effects between the two drugs. Additionally, the hypothesis that the reinforcing effects of psychostimulants are mediated by the same systems that control psychostimulant-induced locomotor activity was examined by conducting correlational studies between drug-induced locomotor activity and time spent in the drug-conditioned compartments. Several doses of cocaine (1.0, 3.0, 5.6, 10.0 mg/kg), and caffeine (0.32, 1.0, 3.2, 5.6, 10.0) were found to condition place preference and stimulate locomotor activity. A combination of low doses (0.32 mg/kg) of each drug appeared to be additive. A positive relationship between locomotor activity observed during conditioning and time spent in the conditioned compartment during testing was found for cocaine but not caffeine or the low-dose combination of cocaine and caffeine.
机译：使用条件部位偏爱（CPP）来阐明几种剂量的可卡因和咖啡因（0.32、1.0、3.2、5.6和10.0 mg / kg）的增强和运动刺激作用，并探讨两种药物之间加和作用的可能性。另外，通过进行药物诱导的运动活动与在药物条件隔室中花费的时间之间的相关研究，检验了精神刺激药的增强作用由控制精神刺激药诱导的运动活动的相同系统介导的假设。发现几剂可卡因（1.0、3.0、5.6、10.0 mg / kg）和咖啡因（0.32、1.0、3.2、5.6、10.0）可以调节位置偏好并刺激运动能力。每种药物的低剂量（0.32 mg / kg）组合似乎是加和的。发现可卡因而不是咖啡因或可卡因和咖啡因的低剂量组合在调理期间观察到的运动活动与测试期间在调理室中花费的时间之间呈正相关。

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