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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Ethanol-induced conditioned place aversion in rats: effect of interstimulus interval.
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Ethanol-induced conditioned place aversion in rats: effect of interstimulus interval.

机译：乙醇诱导的大鼠条件性地方厌恶：刺激间隔的影响。

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摘要

The purpose of this study was to examine the effect of interstimulus interval (ISI) on ethanol-induced place aversion in rats. Six groups of rats initially received four pairings of a distinctive floor stimulus (CS+) with ethanol (1 g/kg, I.P.) and four pairings of a different floor stimulus (CS-) with saline. Groups -30, -15, -10, -5, 0, and 5 were injected 30, 15, 10, 5, or 0 min before, or 5 min after exposure to the 5 min CS, respectively. After testing for place aversion, all groups were exposed to an additional set of conditioning trials using a higher dose of ethanol (1.5 g/kg). During the first test, only groups 0 and -15 exhibited conditioned place aversion. However, during the second test, all groups showed conditioned aversion except group -30. The results suggest that ethanol's aversive effects dissipate by 30 min postinjection or that it is more difficult to associate those effects with short-duration external stimuli at long backward intervals. In contrast to recent findings with mice, the direction of ethanol-induced place conditioning was not altered in rats exposed to different ISIs.
机译：这项研究的目的是检查间质间隔（ISI）对大鼠乙醇诱导的位置厌恶的影响。六组大鼠最初接受四对不同的底刺激（CS +）和乙醇（1 g / kg，I.P.）和四对不同的底刺激（CS-）和生理盐水。分别在暴露于5分钟CS的30分钟，15分钟，10分钟，5分钟或0分钟或之后5分钟注射-30，-15，-10，-5、0和5组。在测试了对位置的厌恶之后，所有组都接受了使用更高剂量的乙醇（1.5 g / kg）的另一组条件试验。在第一个测试中，只有第0和-15组表现出条件性位置反感。但是，在第二次测试中，除-30组外，所有组均显示条件厌恶。结果表明，乙醇的厌恶作用在注射后30分钟消失，或者更难以将这些作用与短时间的外部刺激以较长的向后间隔联系起来。与最近的小鼠发现相反，暴露于不同ISI的大鼠中乙醇诱导的位置调节的方向没有改变。

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