• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Relationship of components of an alcohol interoceptive stimulus to induction of desire for alcohol in social drinkers.
【24h】

Relationship of components of an alcohol interoceptive stimulus to induction of desire for alcohol in social drinkers.

机译：酒精感受性刺激的成分与社交饮酒者对酒精欲望的诱导之间的关系。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The ability of a low (0.2 g/kg) oral dose of ethanol to provide a drug discriminative stimulus was studied in young healthy human volunteers, who were social drinkers. Seventeen of 24 subjects acquired the discrimination following 10 trials in which they received aliquots of ethanol or of placebo drink (tonic water mixed with Tabasco sauce). In generalization studies, in which the dose of ethanol was varied, discrimination performance was dose dependent; doses greater than 0.05 g/kg gave rise to significant ethanol-appropriate responding. Concurrent estimates of the subjective effects of doses administered as discriminative stimuli revealed that two factors--taste and light-headedness--were associated with discrimination: at the training dose, 0.2 g/kg, although both the factors taste and light-headedness were significantly increased, only taste predicted discrimination performance. At lower doses, taste did not contribute to discrimination, but the subjective rating light-headedness correlated significantly with discrimination accuracy. Post hoc analyses of the influence of the amount of alcohol regularly drunk by the volunteers, on discrimination performance suggested light-headedness correlated with discriminative performance only in social drinkers drinking more than 20 units per week. In a second experiment, groups of "high" (mean 40 units per week) and "low" (mean 10 units per week) social drinkers were prospectively identified. Discrimination performance of 0.2 g/kg ethanol in orange juice vs. orange juice vehicle indicated that both groups were able to perform the discrimination following a single training trial, and that generalization curves over the range 0.05-0.2 g/kg were dose dependent, and not different between the groups. At the lowest dose, discrimination performance was predicted by taste, stimulation, and light-headedness in the "high" group, but not in the "low" group. The ability of these ethanol doses to induce feelings of craving for ethanol were assessed in parallel, using the Desire for Alcohol Questionnaire (DAQ). "High" drinkers showed higher desire for ethanol on all factors of the DAQ except the "positive negative reinforcement" factor, and sampling ethanol tended to increase desire in these measures. However, at each dose, the induction of feelings of desire for ethanol showed a negative correlation with discrimination performance. These findings are discussed in the context of the ability of animals and humans to use several components of drug-induced stimuli in the performance of drug discrimination, and the role of such discriminative stimuli in priming of ethanol drinking.
机译：在社交饮酒者的年轻健康人类志愿者中研究了低剂量（0.2 g / kg）乙醇口服液提供药物区分性刺激的能力。在进行10项试验后，有24名受试者中的17名获得了歧视，他们分别接受了乙醇或安慰剂饮料（补给水和塔巴斯科酱混合）的等分试样。在泛化研究中，乙醇的剂量是变化的，鉴别性能是剂量依赖性的。大于0.05 g / kg的剂量会引起明显的乙醇反应。同时判别作为歧视性刺激的剂量的主观效果表明，两个因素-味觉和头昏眼花-与歧视有关：在训练剂量为0.2 g / kg时，尽管两个因素味觉和头昏眼花都是显着增加，只有味道可以预测辨别性能。在较低剂量下，味道没有助于辨别力，但主观评分轻浮与辨别力准确性显着相关。对志愿者经常喝酒的酒精量对歧视表现的事后分析表明，只有在每周饮酒超过20单位的社交饮酒者中，头昏眼花与歧视性表现相关。在第二个实验中，前瞻性地确定了“高”（平均每周40个单位）和“低”（平均每周10个单位）社交饮酒者的组。橙汁与橙汁媒介物中0.2 g / kg乙醇的判别性能表明，在一次训练试验后，两组均能够进行判别，并且0.05-0.2 g / kg范围内的泛化曲线与剂量有关，并且两组之间没有什么不同。在最低剂量下，“味觉”，“刺激”和“头晕”的预测表现是“高”组的，而“低”组则没有。使用“酒精问卷调查表”（DAQ）平行评估了这些乙醇剂量引起对乙醇的渴望的能力。在“ DAQ”的所有因素中，“高”饮酒者对乙醇的需求都高于“正负强化”因素，而在这些措施中，对乙醇进行采样往往会增加对乙醇的需求。然而，在每种剂量下，对乙醇的渴望感的诱导与辨别能力呈负相关。在动物和人类利用药物诱导的刺激的几种成分进行药物区分的能力以及此类歧视性刺激在引发乙醇饮用中的作用的背景下讨论了这些发现。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号