• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >The acute effects of monoamine reuptake inhibitors on the stimulus effects of hallucinogens.
【24h】

The acute effects of monoamine reuptake inhibitors on the stimulus effects of hallucinogens.

机译：单胺再摄取抑制剂对致幻剂的刺激作用的急性作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In a previous study it was observed that fluoxetine potentiates the stimulus effects of lysergic acid diethylamide (LSD). In the present investigation, stimulus control was established in groups of rats using as training drugs the hallucinogens lysergic acid diethylamide (LSD); 0.1 mg/kg), (-)-2,5-dimethoxy-4-methylamphetamine [(-)-DOM; 0.56 mg/kg], ibogaine (10 mg/kg), and 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT; 3 mg/kg). A two-lever, fixed-ratio 10, positively reinforced task with saline controls was employed. The hypotheses tested were that (a) monoamine uptake inhibitors other than fluoxetine potentiate the discriminative effects of LSD, and (b) hallucinogens other than LSD are potentiated by acute pretreatment with monoamine uptake inhibitors. The effects of a range of doses of each of the training drugs were determined both alone and following pretreatment with the monoamine reuptake inhibitors fluoxetine, fluvoxamine, and venlafaxine. In LSD-trained subjects, all three reuptake inhibitors caused a significant increase in LSD-appropriate responding. Similar results were observed in rats trained with (-)-DOM and with ibogaine. In 5-MeO-DMT-trained subjects, only fluoxetine resulted in an enhancement of drug-appropriate responding. The reuptake inhibitors given alone elicited varying degrees of responses appropriate for the respective training drugs. For fluoxetine in rats trained with LSD and ibogaine, for venlafaxine in LSD trained, and for fluvoxamine in (-)-DOM trained, the degree of responding met our criterion for intermediate responding, i.e., significantly different from both training conditions. Subsequent experiments in (-)-DOM-trained subjects examined a range of doses of each of the reuptake inhibitors in combination with a fixed dose of (-)-DOM (0.1 mg/kg), which alone yielded about 50% (-)-DOM-appropriate responding. With the exception of the point obtained with the highest dose of venlafaxine, all data were compatible with additivity of effects rather than true potentiation. In summary, the present data extend our previous observation of the augmentation of the stimulus effects of LSD by fluoxetine to include other hallucinogens. The mechanisms by which these interactions arise and possible differential effects of acute and chronic treatment remain to be established.
机译：在先前的研究中，观察到氟西汀增强了麦角酰二乙胺（LSD）的刺激作用。在本研究中，以致幻剂麦角酰二乙酰胺（LSD）作为训练药物，在大鼠组中建立了刺激控制; 0.1 mg / kg），（-）-2,5-二甲氧基-4-甲基苯丙胺[（-）-DOM; 0.56 mg / kg]，伊博加因（10 mg / kg）和5-甲氧基-N，N-二甲基色胺（5-MeO-DMT; 3 mg / kg）。采用两杆固定比率10的正强化任务，并带有盐水控制。检验的假设是：（a）氟西汀以外的单胺摄取抑制剂可增强LSD的鉴别作用;（b）LSD以外的致幻剂可通过用单胺摄取抑制剂进行的急性预处理来增强。单独和在用单胺再摄取抑制剂氟西汀，氟伏沙明和文拉法辛进行预处理后，分别确定每种训练药物在一定剂量范围内的作用。在接受LSD训练的受试者中，所有三种再摄取抑制剂均导致LSD适当反应的显着增加。在接受（-）-DOM和依博加因训练的大鼠中观察到了相似的结果。在接受5-MeO-DMT训练的受试者中，仅氟西汀可增强药物适当的应答。单独给予的再摄取抑制剂引起适合于各个训练药物的不同程度的反应。对于接受LSD和依博加因训练的大鼠中的氟西汀，经过LSD训练的文拉法辛以及（-）-DOM受过训练的氟伏沙明，其响应程度均符合我们的中等响应标准，即与两种训练条件均存在显着差异。随后在（-）-DOM训练的受试者中进行的实验检查了每种再摄取抑制剂的剂量范围，以及固定剂量的（-）-DOM（0.1 mg / kg），单独产生约50％（-） -适当的DOM响应。除了使用最高剂量的文拉法辛获得的结果外，所有数据均与效应的加性（而不是真实的增效作用）兼容。总而言之，本数据扩展了我们先前对氟西汀对LSD刺激作用的增强作用的观察结果，以包括其他致幻剂。这些相互作用产生的机制以及急性和慢性治疗可能产生的不同作用仍有待建立。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号