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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Lack of effect of the 5-HT(1A) receptor antagonist WAY-100635 on murine agonistic behaviour.
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Lack of effect of the 5-HT(1A) receptor antagonist WAY-100635 on murine agonistic behaviour.

机译：5-HT（1A）受体拮抗剂WAY-100635对鼠的激动行为缺乏影响。

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摘要

The present study examined the influences of the selective 5-HT1A receptor antagonist, WAY-100635, on the social and agonistic behavior exhibited by male resident mice during encounters with unfamiliar intruder conspecifics. Acute administration of WAY-100635 (0.01-1.0 mg/kg sc) dose dependently enhanced the duration of resident maintenance behavior, reaching statistical significance at 1.0 mg/kg. The duration of resident attend/approach behavior was reduced at 0.01 mg/kg. Drug-free intruder animals showed a reduction in the frequency and duration of attend/approach behavior when the resident mice were treated with 0.01 mg/kg WAY-100635. No other significant effects on behavior were detected for WAY-100635. A previous investigation reported that WAY-100635 induced anxiolytic-like effects in the mouse light/dark box test. In the present study, however, the level of defensive behavior of the saline-treated resident mice was too low for any further anxiolytic-like attenuation of this behavior to be observed. Therefore, no conclusions regarding the potential anxiolytic activity of WAY-100635 may be drawn from the data presented here. Current results are consistent with data for the lack of effect of WAY-100635 on rat agonistic behavior but contrast with findings for the effects of the 5-HT1A receptor antagonists (+)-WAY-100135 and SDZ 216-525 on mouse agonistic behavior.
机译：本研究研究了选择性5-HT1A受体拮抗剂WAY-100635对雄性常驻小鼠在遇到陌生入侵者特定物种时表现出的社交和激动行为的影响。 WAY-100635（0.01-1.0 mg / kg sc）的急性给药剂量依赖性地增加了居民维持行为的持续时间，达到1.0 mg / kg时具有统计学意义。居民参加/接近行为的持续时间减少为0.01 mg / kg。当用0.01 mg / kg WAY-100635处理驻留小鼠时，无毒的入侵动物表现出参与/接近行为的频率和持续时间的减少。对于WAY-100635，未检测到对行为的其他显着影响。先前的一项研究报告称，WAY-100635在小鼠明/暗盒测试中诱导了类似抗焦虑的作用。然而，在本研究中，用盐水处理的常驻小鼠的防御行为水平太低，无法观察到这种行为的进一步抗焦虑样减弱。因此，从此处提供的数据可能无法得出有关WAY-100635潜在抗焦虑活性的结论。目前的结果与WAY-100635对大鼠激动行为缺乏影响的数据一致，但与5-HT1A受体拮抗剂（+）-WAY-100135和SDZ 216-525对小鼠激动行为影响的发现相反。

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