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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effects of SR141716A on diazepam substitution for delta9-tetrahydrocannabinol in rat drug discrimination.
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Effects of SR141716A on diazepam substitution for delta9-tetrahydrocannabinol in rat drug discrimination.

机译：SR141716A对地西epa替代delta9-tetrahydrocannabinol的影响。

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摘要

Interaction of cannabinoids with GABAergic systems has been noted in a number of previous studies. In the present study, this interaction was examined in a drug-discrimination paradigm. Rats were trained to discriminate either delta9-tetrahydrocannabinol (delta9-THC; 3 mg/kg) or diazepam (2.5 mg/kg) from vehicle in two-lever drug discrimination procedures for food reinforcement. As in previous studies, diazepam partially substituted for delta9-THC, but only at high doses that also decreased response rates. In contrast, delta9-THC did not substitute for diazepam in any of the rats. Hence, cross-generalization of these two drugs was asymmetrical. When tested in combination with diazepam, the brain cannabinoid (CB1) receptor antagonist SR141716A did not block the partial substitution of diazepam for delta9-THC, nor did it antagonize the discriminative stimulus effects of diazepam in diazepam-trained rats. These results suggest that the partial overlap in the discriminative stimulus effects of delta9-THC and diazepam is not mediated by diazepam action at CB1 receptors. However, the fact that diazepam produced partial substitution for delta9-THC is consistent with a GABAergic component to cannabinoid drug discrimination.
机译：先前的许多研究都指出了大麻素与GABA能系统的相互作用。在本研究中，这种相互作用是在毒品歧视范式中进行的。对大鼠进行了训练，以通过两杆药物鉴别程序从食物中鉴别出delta9-四氢大麻酚（delta9-THC; 3 mg / kg）或地西epa（2.5 mg / kg），以强化食品。与以前的研究一样，地西epa部分替代了delta9-THC，但仅在高剂量时才会降低应答率。相反，在任何大鼠中，delta9-THC都不能替代地西epa。因此，这两种药物的交叉概括是不对称的。当与地西combination联合测试时，脑大麻素（CB1）受体拮抗剂SR141716A不会阻止地西epa部分替代delta9-THC，也不会拮抗地西m对训练过的地西az的歧视性刺激作用。这些结果表明，delta9-THC和地西epa的区别性刺激作用中的部分重叠不是由地西epa对CB1受体的作用介导的。但是，地西epa产生部分替代delta9-THC的事实与大麻素药物区分的GABA能成分一致。

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