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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Flavor preferences conditioned by intragastric ethanol with limited access training.
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Flavor preferences conditioned by intragastric ethanol with limited access training.

机译：口味偏好受胃内乙醇限制进入训练的限制。

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摘要

In a prior study, ad libitum fed rats learned a strong preference (90%) for a flavored saccharin solution (conditioned stimulus, CS+) paired with concurrent intragastric (IG) infusions of 5% ethanol over another flavor (CS-) paired with water infusions in unlimited access sessions (22 h/day). The present study expanded the investigation of ethanol-conditioned preferences to limited access sessions (30 min/day). Experiment 1 revealed that ad lib or food-restricted rats failed to develop a CS+ preference using the same CS solutions (0.05% Kool-Aid+0.2% saccharin) and IG infusions that were effective with long-term training. Experiments 2 and 3 mimicked the parameters from a report of successful ethanol conditioning in deprived rats: ethanol (0.5 g/kg) or water was infused intragastrically 5 min before access to sweetened CS solutions flavored with HCl or NaCl. Rats learned to prefer the ethanol-paired CS+ when the flavors were mixed with 5% sucrose but not when mixed with 0.2% saccharin. Experiment 4 revealed that 5% sucrose solutions flavored with 0.25% Kool Aid also supported flavor preference conditioning by IG ethanol (0.5 g/kg). CS+ preferences were obtained in rats trained with ethanol infused 5 min before or concurrent with CS+ intake, but not in rats trained with ethanol infused 30 min before CS+ intake. These data confirm that flavor preferences can be conditioned by IG ethanol using a limited access procedure. However, in contrast to 22 h/day training, 30 min/day training requires more intense CS flavors and a nutritive sweetener. The preference reinforcing actions of ethanol may develop slowly and are thus most effective with long training sessions or when intense CS flavors are used in short training sessions.
机译：在一项先前的研究中，随意喂养的大鼠对加糖精溶液（条件刺激，CS +）配以并发的胃内（IG）5％乙醇输注比另一种加味（CS-）加水配对具有强烈的偏好（90％）在无限制访问会话中输注（22小时/天）。本研究将对乙醇条件下的偏爱的研究扩大到有限的访问时段（30分钟/天）。实验1显示，使用长期训练有效的相同的CS溶液（0.05％Kool-Aid + 0.2％糖精）和IG输注，ad lib或食物受限的大鼠未能表现出CS +偏爱。实验2和3模仿了剥夺大鼠成功进行乙醇调理的报告中的参数：在获得用HCl或NaCl调味的增甜CS溶液之前，胃内注入乙醇（0.5 g / kg）或水5分钟。当调味剂与5％蔗糖混合时，大鼠学会了偏爱与乙醇配对的CS +，而与0.2％糖精混合时，老鼠则不喜欢。实验4表明用0.25％Kool Aid调味的5％蔗糖溶液还支持通过1G乙醇（0.5g / kg）进行的风味偏爱调节。 CS +偏爱是在CS +摄入前5分钟或与之同时接受乙醇训练的大鼠中获得的，而不是在CS +摄入前30分钟接受乙醇训练的大鼠中获得的。这些数据证实，可以使用有限的获取程序通过IG乙醇调节风味偏好。但是，与每天22小时的训练相反，每天30分钟的训练需要更强烈的CS风味和营养甜味剂。乙醇的偏爱增强作用可能会缓慢发展，因此在长时间的培训中或在短期的培训中使用强烈的CS风味时最有效。

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