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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >The effects of habitual caffeine use on cognitive change: a longitudinal perspective.
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The effects of habitual caffeine use on cognitive change: a longitudinal perspective.

机译：习惯性咖啡因的使用对认知变化的影响：纵向观点。

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The efficiency of higher cortical functions, such as memory and speed of complex information processing, tends to decrease with advancing age in normal healthy individuals. Recently, a high habitual intake of caffeine was found associated with better verbal memory performance and psychomotor speed in several cross-sectional population studies. We tested the hypothesis that habitual caffeine intake can reduce or postpone age-related cognitive decline in healthy adults. For this purpose, the cognitive performance of all participants in the Maastricht Aging Study (MAAS), aged between 24 and 81 years, was reassessed after 6 years. Information on the intake of caffeine-containing beverages was available from the baseline questionnaire. After 6 years, 1376 (75.6%) individuals were available for reassessment. After correction for demographic characteristics, baseline performance and health status, there were small albeit significant associations between the overall estimated caffeine intake at baseline and the 6-year change in complex motor speed (motor choice reaction time). The earlier found association between caffeine intake and verbal memory performance was not apparent in this longitudinal study. These results imply that the longitudinal effect of habitual caffeine intake is limited and will not promote a substantial reduction in age-related cognitive decline at a population level.
机译：正常健康人的年龄随着年龄的增长，皮质功能的效率（例如记忆和复杂信息处理的速度）往往会降低。最近，在一些横断面人群研究中，发现咖啡因的习惯摄入量较高，这与更好的言语记忆能力和心理运动速度有关。我们测试了在健康成年人中习惯性摄入咖啡因可以减少或推迟与年龄有关的认知下降的假设。为此，对年龄在24至81岁之间的马斯特里赫特老龄研究（MAAS）中所有参与者的认知表现进行了6年后的重新评估。有关含咖啡因饮料摄入量的信息可从基线调查表中获得。 6年后，有1376（75.6％）个人可以进行重新评估。在校正了人口统计学特征，基线表现和健康状况后，基线时咖啡因的总体估计摄入量与复杂运动速度（运动选择反应时间）的6年变化之间存在很小的联系，尽管两者之间存在显着关联。在这项纵向研究中，咖啡因摄入与言语记忆能力之间的较早发现并不明显。这些结果表明，习惯性摄入咖啡因的纵向影响是有限的，并且不会促进人口水平上与年龄有关的认知能力下降的实质性减少。

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