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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Midazolam does not influence intravenous fentanyl-induced analgesia in healthy volunteers.
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Midazolam does not influence intravenous fentanyl-induced analgesia in healthy volunteers.

机译：咪达唑仑不影响健康志愿者中静脉注射芬太尼引起的镇痛作用。

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摘要

The effects of saline and intravenous midazolam (0.5, 1, and 2 mg per 70 kg) in combination with intravenous fentanyl (0.1 mg/70 kg) were examined on pain induced by a cold pressor test. Healthy volunteers (six females, six males) were enrolled in a prospective, double-blind, randomized, crossover trial in which mood and psychomotor performance were also examined. Five minutes and 135 min postinjection subjects immersed their forearm in ice cold water for 3 min while assessments of pain were recorded. During the first immersion, subjects reported significantly lower pain intensity and bothersomeness ratings after having been injected with fentanyl, relative to the saline condition, but the addition of midazolam neither increased nor decreased pain reports. During the second immersion (approximately 2.5 h postinjection) pain ratings did not differ between the drug and saline conditions. Mood-altering and psychomotor-impairing effects of the drug combination were dose related. We conclude that midazolam at the doses and route of administration tested neither potentiates nor decreases the analgesia produced by fentanyl in a cold-pressor pain assay.
机译：观察了盐水和静脉给予的咪达唑仑（每70千克0.5毫克，1毫克和2毫克）与静脉注射芬太尼（0.1毫克/ 70千克）的组合对冷压试验引起的疼痛的影响。健康的志愿者（六名女性，六名男性）参加了一项前瞻性，双盲，随机，交叉试验，其中还检查了情绪和心理运动表现。注射后五分钟和135分钟，受试者将前臂浸入冰冷水中3分钟，同时记录疼痛评估。在第一次浸泡过程中，受试者被注射芬太尼后的疼痛强度和打扰程度明显低于盐溶液，但添加咪达唑仑既没有增加也没有减轻疼痛的报道。在第二次浸泡期间（注射后约2.5小时），药物和生理盐水条件下的疼痛等级没有差异。药物组合的情绪改变和精神运动损害作用与剂量有关。我们得出的结论是，在冷压痛试验中，咪达唑仑在所测试的剂量和给药途径下既不会增强也不会降低芬太尼产生的镇痛作用。

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