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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effects of the serotonin receptor agonists 8-OH-DPAT and TFMPP on learning as assessed using a novel water maze.
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Effects of the serotonin receptor agonists 8-OH-DPAT and TFMPP on learning as assessed using a novel water maze.

机译：使用新型水迷宫评估血清素受体激动剂8-OH-DPAT和TFMPP对学习的影响。

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摘要

We evaluated the effects of two drugs active at serotonin receptors, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT, a 5-HT1A agonist) and N-3-trifluoromethylphenyl)piperazine hydrochloride (TFMPP, a 5-HT2C agonist) on learning using a novel water maze previously characterized in our laboratory. The water maze utilized is a traditional type of maze with alleyways and doors through which the rats learn to swim to reach a platform, unlike the open pool Morris water maze task. Performance is assessed by swim time required to reach the platform and errors committed. Following initial training on maze configuration A, rats were assigned to saline, TFMPP and 8-OH-DPAT treatment groups and tested for performance once per dose, 30 min after administration of drug (0.25, 0.5, and 1.0 mg/kg IP). Swim times were significantly increased as compared to saline for all doses for both drugs. The error rate was increased for 8-OH-DPAT at all doses, while TFMPP had no effect on error rate at any dose. Next, rats werechallenged to learn new mazes following daily administration of 0.25 or 0.5 mg/kg of each drug 30 min prior to each daily swim trial. Rats given 0.25 mg/kg of 8-OH-DPAT learned new maze C more slowly than saline-treated rats, while TFMPP had no effect at this dose. At the higher dose of 0.5 mg/kg, tested on new maze B, TFMPP administration significantly increased swim times but not errors, while this dose of 8-OH-DPAT markedly increased both swim time and errors. Finally, rats from all groups were tested on maze E after drug administration was discontinued, and there were no performance differences among groups. These data suggest that serotonin1A receptors may inhibit learning.
机译：我们评估了对5-羟色胺受体有活性的两种药物的作用，即8-hydroxy-2-（di-n-propylamino）tetralin（8-OH-DPAT，5-HT1A激动剂）和N-3-三氟甲基苯基）哌嗪盐酸盐（TFMPP） ，一种5-HT2C激动剂），使用以前在我们实验室中表征过的新型水迷宫学习。所使用的水迷宫是一种带有小巷和门的传统迷宫，老鼠可以通过这些迷宫学习游泳以到达平台，这与开放式莫里斯水迷宫任务不同。通过到达平台所需的游泳时间和所犯的错误来评估性能。在迷宫配置A上进行初始训练后，将大鼠分为生理盐水，TFMPP和8-OH-DPAT治疗组，并在给药后30分钟（剂量分别为0.25、0.5和1.0 mg / kg IP）测试每剂一次的性能。与两种剂量的所有剂量的盐水相比，游泳时间都显着增加。在所有剂量下，8-OH-DPAT的错误率均增加，而TFMPP在任何剂量下均对错误率没有影响。接下来，在每次每日游泳试验之前30分钟每天给予0.25或0.5 mg / kg的每种药物，然后挑战大鼠学习新的迷宫。给予0.25 mg / kg 8-OH-DPAT的大鼠学习新迷宫C的速度比盐水处理的大鼠慢，而TFMPP在该剂量下则没有作用。在新的迷宫B上测试，以0.5 mg / kg的较高剂量使用TFMPP可以显着增加游泳时间，但不会增加错误发生，而这种8-OH-DPAT剂量则显着增加了游泳时间和错误发生时间。最后，停止给药后，在迷宫E上对所有组的大鼠进行测试，各组之间无性能差异。这些数据表明，血清素1A受体可能抑制学习。

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