• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Neonatal organizational effects of the 5-HT2 and 5-HT1A subsystems on adult behavior in the rat.
【24h】

Neonatal organizational effects of the 5-HT2 and 5-HT1A subsystems on adult behavior in the rat.

机译：5-HT2和5-HT1A子系统对大鼠成年行为的新生儿组织作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Males, females, neonatally androgenized females, and neonatally castrated males were treated over the second week of life with 0.25 mg/kg of either the 5-HT2 agonist 1-(2,5-dimethoxy-3-iodophenyl)-2-aminopropane HCl (DOI), the 5-HT2 antagonist ritanserin (Rit), the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), or the 5-HT1A antagonist WAY100135 (WAY). Exploration, anxiety, sociosexual preferences, and sexual behavior were measured in adulthood. Agents acting on 5-HT1A receptors do not appear to affect organization of any of the behavioral systems studied. DOI increased exploratory activity but in females only, which suggests that testosterone antagonizes the stimulatory effect of 5-HT2 activity on exploration. Neonatal ritanserin selectively reduced anxiety in females, and DOI had a similar effect in androgenized females. This indicates that neonatal 5-HT2 activity is anxiogenic in normal females, anxiolytic in androgenized females, and has no effect on anxiety in males. Males and androgenized females both showed a preference for the female teaser that was abolished by the 5-HT2 agonist, DOI. These results point out that 5-HT2 activity selectively suppresses heterosexual preference induced in the presence of neonatal testosterone. DOI also reduced both male sexual behavior in males and female sexual behavior in androgenized females. Thus, the 5-HT2 system antagonizes the action of testosterone in stimulating heterosexual orientation and sexual activity, and this is independent of genetic sex.
机译：男性，女性，新生儿雄激素化的女性和cast割的男性在生命的第二周内接受0.25 mg / kg的5-HT2激动剂1-（2,5-二甲氧基-3-碘苯基）-2-氨基丙烷HCl的治疗（DOI），5-HT2拮抗剂利坦色林（Rit），5-HT1A激动剂8-羟基-2-（二-正丙基氨基）四氢化萘（8-OH-DPAT）或5-HT1A拮抗剂WAY100135（WAY ）。在成年期测量探查，焦虑，性交偏好和性行为。作用于5-HT1A受体的药物似乎并不影响所研究的任何行为系统的组织。 DOI增加了探索性活动，但仅在女性中，这表明睾丸激素可拮抗5-HT2活性对探索的刺激作用。新生儿利坦色林选择性地减轻了女性的焦虑感，而DOI对雄激素化的女性也具有类似的作用。这表明，新生儿5-HT2活性在正常女性中是焦虑的，在雄激素化的女性中是抗焦虑的，并且对男性的焦虑没有影响。雄性和雄激素化的雌性都表现出对5-HT2激动剂DOI废除的雌性挑逗的偏好。这些结果指出，5-HT 2活性选择性地抑制了在新生儿睾丸激素的存在下诱导的异性恋偏好。 DOI还减少了男性的男性性行为和雄激素化女性的女性性行为。因此，5-HT2系统拮抗睾丸激素刺激异性恋取向和性活动的作用，而这与遗传性别无关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号