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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effects of neonatally administered iprindole on adult behaviors of rats.
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Effects of neonatally administered iprindole on adult behaviors of rats.

机译：新生儿服用艾普利多对大鼠成年行为的影响。

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摘要

In past studies, administration of the antidepressant drugs clorimipramine, zimeldine, or desipramine to neonatal rats produced abnormalities in adult rats that modeled some behavioral and/or REM sleep features of human endogenous depression. Although these three drugs affected different neurotransmitter systems, all caused REM sleep deprivation (RSD). This suggested the hypothesis that RSD of neonatal rats caused their adult depression. One prediction of this hypothesis is that neonatally administered iprindole, an antidepressant drug that does not produce RSD, will not produce adult rats that model depression. The present study tested this hypothesis. Iprindole was administered to neonatal experimental rats and saline was administered to neonatal control rats. When the rats matured, compared with control rats, experimental rats were not significantly different in aggressive behavior (shock induced fighting), sexual behaviors, open field locomotion, and REM sleep. In our previous studies on rats, all these adult behaviors were affected in a depressive-like way by neonatally administered clorimipramine. Because iprindole does not decrease REM sleep, the present results support the hypothesis that in rats neonatal RSD causes adult depression.
机译：在过去的研究中，对新生大鼠施用抗抑郁药克罗米帕明，齐美尔定或地昔帕明在成年大鼠中产生了异常，该异常模拟了人类内源性抑郁的某些行为和/或REM睡眠特征。尽管这三种药物影响不同的神经递质系统，但均会引起REM睡眠剥夺（RSD）。这提出了一个假设，即新生大鼠的RSD导致成年抑郁症。该假说的一个预测是，新生儿服用的不产生RSD的抗抑郁药伊普利多不会产生模拟抑郁症的成年大鼠。本研究检验了这一假设。对新生实验大鼠施用异丙多酚，对新生对照组大鼠给予生理盐水。当大鼠成熟时，与对照大鼠相比，实验大鼠在攻击行为（休克引起的战斗），性行为，开阔地运动和REM睡眠方面没有显着差异。在我们先前对大鼠的研究中，所有这些成年行为都受到新生儿服用克罗米帕明的抑制作用。因为艾普环不会降低REM睡眠，所以本研究结果支持以下假设：大鼠RSD会导致成年抑郁。

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