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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Muscarinic antagonists are anxiogenic in rats tested in the black-white box.
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Muscarinic antagonists are anxiogenic in rats tested in the black-white box.

机译：毒蕈碱拮抗剂在黑白框中测试的大鼠中具有抗焦虑作用。

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Central cholinergic (ACh) projections have been shown to modulate stress-induced activation of the hypothalamic-pituitary-adrenal (HPA) axis and are integral to the expression of electrophysiological correlates of arousal, namely hippocampal theta rhythm. The degree to which these actions of ACh are behaviorally relevant has received comparatively less attention, and we sought to investigate if manipulations of ACh systems might also affect behaviors related to stress and arousal. We chose to examine indices of anxiety as revealed by changes in behavior elicited by the black-white box test, a relatively novel and recently validated model of rodent anxiety. Groups of rats were injected with either scopolamine hydrobromide (SCOP; 0, 0.05, and 0.10 mg/kg i.p.) or the peripherally acting scopolamine methyl bromide (methyl-SCOP; 0, 0.05, and 0.10 mg/kg i.p.) to compare and contrast the effects of central and peripheral ACh blockade on measures of anxiety. SCOP pretreatment significantly lowered latencies for rats to escape from the white to black compartment, while methyl-SCOP elevated latencies to reenter the white chamber from the black. Both drugs increased the amount of time rats spent in the black compartment and also suppressed exploration as revealed by decreased episodes of intercompartmental locomotion. Neither drug deleteriously affected locomotor activity, however; in fact, SCOP significantly increased locomotion in the white chamber. In the absence of motor disturbances to account for any group differences, we contend that both central and peripheral ACh blockade may affect measures of anxiety, perhaps by directly or indirectly affecting HPA activity. Central ACh systems may underlie sensory filtering whereby irrelevant stimuli are excluded from sensory processing. Antagonism of ACh transmission may render an animal incapable of correctly processing sensory information leading to hyperresponsiveness, which can manifest itself as enhanced anxiety and fear.
机译：中央胆碱能（ACh）预测已显示出调节应激诱导的下丘脑-垂体-肾上腺（HPA）轴的激活，并且是觉醒的电生理相关性（即海马theta节律）表达的组成部分。 ACh的这些行为与行为相关的程度受到的关注相对较少，我们试图研究ACh系统的操纵是否还会影响与压力和唤醒有关的行为。我们选择检查焦虑指数，该指数是由黑盒试验（一种相对新颖且最近经过验证的啮齿动物焦虑模型）引起的行为变化所揭示的。每组大鼠注射东碱氢溴酸盐（SCOP; 0、0.05和0.10 mg / kg ip）或外围作用的东pol碱甲基溴（甲基-SCOP; 0、0.05和0.10 mg / kg ip）进行比较和对比中枢和外周ACh阻滞对焦虑程度的影响。 SCOP预处理显着降低了大鼠从白色到黑色隔室逃脱的潜伏期，而甲基-SCOP则增加了从黑色进入白色腔室的潜伏期。两种药物都增加了大鼠在黑色隔室中度过的时间，并且还减少了间隔间运动的发作，从而抑制了探索。但是，两种药物均不会有害地影响运动能力。实际上，SCOP显着增加了白室内的运动。在没有运动障碍来说明任何群体差异的情况下，我们认为中枢和外周ACh阻滞均可能通过直接或间接影响HPA活性来影响焦虑程度。中央ACh系统可以作为感觉过滤的基础，从而无关的刺激被排除在感觉处理之外。 ACh传递的拮抗作用可能导致动物无法正确处理导致过度反应的感觉信息，而过度反应又可能表现为焦虑和恐惧。

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