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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Activation of the immune system in rats with lipopolysaccharide reduces voluntary sucrose intake but not intraoral intake.
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Activation of the immune system in rats with lipopolysaccharide reduces voluntary sucrose intake but not intraoral intake.

机译：用脂多糖激活大鼠的免疫系统会减少自愿摄入的蔗糖，但不会减少口腔内的摄入。

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Traditional intake measures of voluntary consumption of food or fluid from a specific location involve both appetitive and consummatory behaviors. Appetitive behaviors are food finding behaviors displayed by an animal prior to the consumption of the food, whereas consummatory behaviors are the behaviors involved in the actual consumption of the food. Intraoral intake of a fluid can be measured by directly infusing it into the oral cavity of an animal and quantifying the consummatory behaviors. The present study compared the effects of immune activation (lipopolysaccharide, LPS) and toxin (lithium chloride, LiCl)-induced changes on both a traditional intake measure (bottle drinking) and an intraoral intake measure. In Experiment 1, rats were injected intraperitoneally with LPS (200 microg/kg), LiCl (0.15 M, 20 ml/kg) or NaCl vehicle, and voluntary sucrose (0.3 M) intake was monitored for 1 h from a graduated drinking tube. Voluntary intake was again assessed on a second test day, 72 h later under the same conditions. In Experiment 2, a continuous intraoral infusion of sucrose (0.3 M) was given via intraoral cannulae following systemic injections of LPS, LiCl or NaCl vehicle on two different test days, 72 h apart. Rats injected with LiCl displayed reduced sucrose intake on both the voluntary intake measure and the intraoral intake measure relative to controls (P's<.05). The reduced intake observed was of greater magnitude on the second test day of both experiments, consistent with conditioning effects. In contrast, LPS reduced sucrose intake only when assessed with the traditional intake measure. Intraoral sucrose intake remained unchanged relative to controls. The present results provide further evidence that activation of the immune system has adverse effects on the appetitive phase of ingestion, whereas the consummatory aspects are unaffected.
机译：自愿从特定地点食用食物或液体的传统摄入量测量方法既涉及饮食行为，也涉及消费行为。食欲行为是动物在食用食物之前表现出的觅食行为，而消费行为是实际食用食物所涉及的行为。可以通过将液体直接注入动物的口腔并量化其消费行为来测量其口腔内摄入量。本研究比较了免疫激活（脂多糖，LPS）和毒素（氯化锂，LiCl）诱导的变化对传统摄入量（喝瓶）和口内摄入量的影响。在实验1中，给大鼠腹膜内注射LPS（200 microg / kg），LiCl（0.15 M，20 ml / kg）或NaCl载体，并从量筒中监测自愿摄入的蔗糖（0.3 M）1 h。在相同条件下72小时后的第二个测试日再次评估自愿摄入量。在实验2中，在相隔72小时的两个不同测试日中，系统性注射LPS，LiCl或NaCl载体后，通过口腔内插管连续口服口服蔗糖（0.3 M）。注射LiCl的大鼠在自愿摄入量和口腔内摄入量方面均显示出相对于对照组的蔗糖摄入量减少（P's <.05）。在两个实验的第二个测试日，观察到的摄入量减少幅度更大，这与调节作用一致。相比之下，LPS仅在使用传统摄入量评估时才降低蔗糖摄入量。相对于对照组，口内蔗糖摄入量保持不变。目前的结果提供了进一步的证据，表明免疫系统的激活对消化的食欲阶段有不利影响，而消费方面却不受影响。

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