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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Prior exposure to phencyclidine decreases voluntary sucrose consumption and operant performance for food reward.
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Prior exposure to phencyclidine decreases voluntary sucrose consumption and operant performance for food reward.

机译：事先接触苯环利定可减少自愿性蔗糖的消耗，并减少食物奖励的操作性能。

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Prior exposure to the psychotomimetic drug phencyclidine (PCP) produces a number of schizophrenia-like behaviors in animals. The goal of the present study was to determine whether prior exposure to PCP produces decreased reward function, thereby modeling one aspect of negative schizophrenic symptomatology. To this aim, the consequences of prior exposure to PCP were assessed on two types of appetitive consumptive behavior. In the first set of experiments, the effects of PCP (15 mg/kg, 20 h before testing) on sucrose consumption were tested for three consecutive days under conditions of deprivation and nondeprivation. In the deprivation condition, animals were water deprived for 4 h prior to injection of PCP or saline (SAL). Twenty hours following the injection (24 h after the onset of water deprivation), animals were allowed access to either 5% sucrose or water for 30 min. In the nondeprivation condition, 5% sucrose consumption was measured for 30 min, 20 h after PCP or SAL injection and water consumption was measured during the 23.5 h preceding sucrose consumption. PCP decreased both sucrose and water consumption under deprivation conditions on the second and third day of testing but selectively decreased sucrose consumption under nondeprivation conditions on all three testing days. LiCl (50 mg/kg, 20 h before testing) did not significantly reduce sucrose consumption in the nondeprivation paradigm, indicating that the effect of PCP was not due to conditioned taste aversion. In the second experiment, PCP (15 mg/kg, 20 h before testing) decreased operant performance when animals were switched from a continuous reinforcement schedule of food delivery to a fixed ratio (FR4) schedule. Apomorphine (APO, 30 microg/kg, 30 min before testing), a positive control, induced a similar performance deficit. However, the PCP-induced deficit was not apparent until the third day of FR4 testing while the APO deficit was apparent on the first day. The effects of PCP on sucrose consumption demonstrate PCP-induced decreases in reward function. However, the delayed appearance of the PCP-induced decrease in operant performance suggests that these results may be better explained by a PCP-induced attentional deficit, also characteristic of schizophrenic psychopathology.
机译：事先暴露于拟精神病药物苯环利定（PCP）中的动物会产生许多精神分裂症样行为。本研究的目的是确定先前是否接触五氯苯酚会降低奖励功能，从而为精神分裂症阴性症状的一个方面建模。为此，对两种类型的消费行为进行了评估，以评估事先接触五氯苯酚的后果。在第一组实验中，在剥夺和不剥夺条件下连续三天测试了五氯苯酚（15毫克/千克，测试前20小时）对蔗糖消耗的影响。在剥夺条件下，在注射PCP或盐水（SAL）之前将动物剥夺水4 h。注射后二十小时（开始缺水后24小时），让动物接触5％蔗糖或水30分钟。在非剥夺条件下，在注射PCP或SAL后20小时的30分钟内，测量了5％的蔗糖消耗量，并在消耗蔗糖之前的23.5小时内测量了水消耗量。在测试的第二天和第三天，五氯苯酚在剥夺条件下减少了蔗糖和水的消耗，但在所有三个测试日中，在非剥夺条件下选择性减少了蔗糖的消耗。 LiCl（50 mg / kg，测试前20小时）在非剥夺范式中并未显着减少蔗糖的消耗，这表明PCP的作用不是由于条件性厌恶引起的。在第二个实验中，当动物从食物供应的连续强化时间表改为固定比例（FR4）时间表时，PCP（15 mg / kg，测试前20小时）降低了操作性能。阳性对照阿扑吗啡（APO，30微克/千克，测试前30分钟）引起类似的性能下降。但是，直到FR4测试的第三天，PCP诱导的缺陷才明显，而APO缺陷在第一天才明显。五氯苯酚对蔗糖消耗的影响表明五氯苯酚诱导的奖赏功能下降。但是，PCP引起的手术性能下降的延迟出现提示，这些结果可能由PCP引起的注意力缺陷（精神分裂症的精神病理学特征）更好地解释。

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