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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Environmental enrichment lowers stress-responsive hormones in singly housed male and female rats.
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Environmental enrichment lowers stress-responsive hormones in singly housed male and female rats.

机译：环境富集降低了单只雌性和雌性大鼠的应激反应激素。

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摘要

Structural and social aspects of an environmental system can influence the physiology and behavior of animals occupying that system. This study examined the physiological effects of environmental enrichment (EE) with Kong Toys and Nestlets on stress-responsive hormones of the hypothalamic-pituitary-adrenal (HPA) axis under basal and mild stress conditions in singly housed, jugular vein-cannulated, male and female rats. Animals of both sexes housed with EE had significantly lower baseline adrenocorticotropic hormone (ACTH) and corticosterone (CORT) concentrations compared to those housed without EE. ACTH responses to the mild stress of saline injection were significantly lower in female rats housed with EE. Interaction with the Kong Toys and Nestlets appears to have provided the rats with a diversion from monotonous cage life, resulting in lower HPA axis activity before and after mild stress. These results are important because low, stable baselines are essential for accurately discerning pharmacological and other influences on the HPA axis.
机译：环境系统的结构和社会方面会影响占据该系统的动物的生理和行为。这项研究研究了在单身，颈静脉插管，男性和单身的基础和轻度压力条件下，使用Kong Toys和Nestlets进行环境富集（EE）对下丘脑-垂体-肾上腺（HPA）轴的应激反应激素的生理影响。雌性大鼠。与没有EE的动物相比，有EE的动物都具有较低的基线促肾上腺皮质激素（ACTH）和皮质酮（CORT）浓度。在雌性EE大鼠体内，盐水注射对轻度应激的ACTH反应明显降低。与Kong Toys和Nestlets的相互作用似乎使大鼠摆脱了单调的笼寿命，导致轻度应激前后HPA轴活性降低。这些结果很重要，因为低而稳定的基线对于准确识别对HPA轴的药理作用和其他影响至关重要。

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