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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Protective effects of pseudoginsenoside-F(11) on methamphetamine-induced neurotoxicity in mice.
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Protective effects of pseudoginsenoside-F(11) on methamphetamine-induced neurotoxicity in mice.

机译：假人参皂甙F（11）对甲基苯丙胺诱发的小鼠神经毒性的保护作用。

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摘要

In the present study, pseudoginsenoside-F(11) (PF(11)), a saponin that existed in American ginseng, was studied on its protective effect on methamphetamine (MA)-induced behavioral and neurochemical toxicities in mice. MA was intraperitoneally administered at the dose of 10 mg/kg four times at 2-h intervals, and PF(11) was orally administered at the doses of 4 and 8 mg/kg two times at 4-h intervals, 60 min prior to MA administration. The results showed that PF(11) did not significantly influence, but greatly ameliorated, the anxiety-like behavior induced by MA in the light-dark box task. In the forced swimming task, PF(11) significantly shortened the prolonged immobility time induced by MA. In the appetitively motivated T-maze task, PF(11) greatly shortened MA-induced prolonged latency and decreased the error counts. Similar results were also observed in the Morris water maze task. PF(11) significantly shortened the escape latency prolonged by MA. There were significant decreases in the contents of dopamine (DA), 3,4-dihydroxyphenacetic acid (DOPAC), homovanillic acid (HVA), and 5-hydroxyindoacetic acid (5-HIAA) in the brain of MA-treated mice. PF(11) could partially, but significantly, antagonize MA-induced decreases of DA. The above results demonstrate that PF(11) is effective in protection of MA-induced neurotoxicity and also suggest that natural products, such as ginseng, might be potential candidates for the prevention and treatment of the neurological disorders induced by MA abuse.
机译：在本研究中，研究了西洋参中存在的皂苷类假人参皂甙-F（11）（PF（11））对甲基苯丙胺（MA）诱导的小鼠行为和神经化学毒性的保护作用。在腹腔注射前60分钟，以10 mg / kg的剂量腹膜内施用四次，每次2小时，以4和8 mg / kg的剂量腹膜内施用PF（11），间隔4小时，两次。 MA管理。结果表明，PF（11）对明暗盒任务中由MA引起的焦虑样行为没有显着影响，但有很大改善。在强制游泳任务中，PF（11）大大缩短了MA导致的长时间不动时间。在具有竞争动机的T型迷宫任务中，PF（11）大大缩短了MA引起的长时间等待时间，并减少了错误计数。在莫里斯水迷宫任务中也观察到了类似的结果。 PF（11）大大缩短了MA延长的逃逸潜伏期。在MA治疗的小鼠的大脑中，多巴胺（DA），3,4-二羟基苯乙酸（DOPAC），高香草酸（HVA）和5-羟基吲哚乙酸（5-HIAA）的含量显着降低。 PF（11）可以部分但显着拮抗MA诱导的DA下降。以上结果表明，PF（11）在保护MA引起的神经毒性方面有效，并且还表明天然产物（例如人参）可能是预防和治疗由MA引起的神经系统疾病的潜在候选者。

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