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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Neonatal cholinergic lesions and development of exploration upon administration of the GABAa receptor agonist muscimol in preweaning rats.
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Neonatal cholinergic lesions and development of exploration upon administration of the GABAa receptor agonist muscimol in preweaning rats.

机译：在断奶前大鼠中给予GABA a受体激动剂麝香酚后，其新生儿胆碱能损害和研究进展。

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Neonatal rats were administered 192 IgG-saporin (192 IgG-Sap), a selective cholinergic immunotoxin, on postnatal day (PND) 7. Behavioural responsiveness to muscimol, a GABAa receptor agonist, was then assessed using locomotor activity and object exploration tests on PND 18. In Experiment 1, 192 IgG-Sap-lesioned and control rats were injected with the GABAa agonist, muscimol, on PND 18 and tested in a standard open field test. Muscimol reduced rearing responses in both control and 192 IgG-Sap-lesioned animals whereas reduced wall-rearing responses occurred in control animals only. 192 IgG-Sap also reduced rearing and wall-rearing responses. In Experiment 2, muscimol effects were evaluated on PND 18 in a spatial open field test in which object exploration in addition to locomotion and rearing responses was assessed. Neonatal cholinergic lesion per se increased locomotion during object exploration while decreasing time spent exploring objects. Depressant effects of muscimol on object exploration were alsoevident. As a whole, these data provide evidence for (i) basal forebrain (BF) cholinergic control on locomotor activity and object exploration and (ii) GABAa-mediated regulation of selective behavioural patterns associated with locomotion and exploration in weaning rats. Neonatal cholinergic lesions, however, do not appear to alter reactivity to GABAergic agonists in juvenile rats.
机译：在新生婴儿出生后一天（PND）7，给予新生大鼠192 IgG-saporin（192 IgG-Sap）（一种选择性胆碱能免疫毒素）。对鼠麝香酚（一种GABA a受体激动剂）的行为反应进行了评估，并使用了运动活性和PND上的对象探索测试18.在实验1中，在PND 18上向192只IgG-Sap损伤的大鼠和对照组大鼠注射了GABAa激动剂麝香酚，并在标准的开放视野试验中进行了测试。 Muscimol在对照组和192个IgG-Sap损伤的动物中均降低了饲养反应，而仅在对照动物中发生了壁培养反应降低。 192 IgG-Sap也减少了饲养和育壁反应。在实验2中，在空间开放野外测试中对PND 18评估了麝​​香酚的作用，该实验评估了运动和饲养响应之外的目标探索。新生儿胆碱能损伤本身在探查对象时增加了运动，同时减少了探查对象所花费的时间。麝香酚对对象探索的抑制作用也很明显。总体而言，这些数据提供了以下证据：（i）基底前脑（BF）对运动活动和对象探索的胆碱能控制，以及（ii）GABAa介导的对断奶大鼠运动和探索相关的选择性行为模式的调节。然而，新生幼年胆碱能损伤似乎并未改变其对GABA能激动剂的反应性。

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