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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Evidence for zolpidem-induced hyperphagia, but not anxiolysis, in a successive negative contrast paradigm.
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Evidence for zolpidem-induced hyperphagia, but not anxiolysis, in a successive negative contrast paradigm.

机译：唑吡坦诱导的食欲亢进的证据，但在连续的负对比范式中没有焦虑症的证据。

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摘要

Zolpidem is an imidazopyridine which binds to certain benzodiazepine receptor types with varying degrees of affinity. The effect of zolpidem on successive negative contrast was investigated in three experiments. In each experiment, a contrast group was given brief access to 32% sucrose for 10 days, then shifted to 4% sucrose for 2 days; a procedure that elicits anxiety primarily on the second postshift day. One control group was given only 4% sucrose. Experiments 2 and 3 included a 2% sucrose group as an intake rate-dependent control. In Experiment 1, zolpidem (4.0 and 0.5 mg/kg) dose-dependently reduced contrast on the two postshift days. Contrast occurred during the first postshift consummatory burst. Zolpidem prolonged the first postshift burst equally in both shifted and unshifted groups, suggesting a general facilitation of intake masked by a ceiling effect in controls. In Experiment 2, zolpidem's (4.0 mg/kg) anti-contrast action was equivalent to its hyperphagic effect in the 2% control group. Zolpidem prolonged the first postshift burst equally in all three groups, again consistent with general intake facilitation. In Experiment 3, 8.0 mg/kg zolpidem produced an anti-contrast effect not present in 2% controls on both postshift days. This does not appear attributable to anxiolysis, however, as the effect was equivalent during stressful and non-stressful phases of the postshift period, and zolpidem extended the duration of the first postshift burst equally in all three sucrose groups. Thus, unlike benzodiazepines, zolpidem is not anxiolytic in this paradigm.
机译：唑吡坦是咪唑并吡啶，其以不同程度的亲和力结合某些苯并二氮杂pine受体类型。在三个实验中研究了唑吡坦对连续阴性对比度的影响。在每个实验中，给对比组短暂使用32％的蔗糖10天，然后换成4％的蔗糖2天。主要在轮班后的第二天引起焦虑的程序。一个对照组仅给予4％的蔗糖。实验2和3包括2％的蔗糖组作为摄入速率依赖性对照。在实验1中，唑吡坦（4.​​0和0.5 mg / kg）在两班后的剂量中剂量依赖性地降低对比度。对比发生在第一个班次后的消费爆发期间。唑吡坦在转移组和未转移组中均同样延长了首次移位后爆发，这表明对照组的上限效应掩盖了摄入的总体便利性。在实验2中，唑吡坦（4.​​0 mg / kg）的抗对比作用等效于2％对照组的高吞噬作用。唑吡坦在所有三组中均平均延长了首次换班后猝发，再次与一般摄入促进相一致。在实验3中，8.0 mg / kg唑吡坦产生的抗对比作用在两个班后的两天中均不存在。这似乎不归因于抗焦虑作用，但是，在后班期间的紧张和非紧张阶段，这种作用是等效的，并且唑吡坦在所有三个蔗糖组中均等地延长了首个班后突发的持续时间。因此，与苯并二氮杂unlike不同，唑吡坦在该范例中不抗焦虑。

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