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Anxiolytic properties of the antipsychotic alkaloid alstonine.

机译：抗精神病药碱生物碱的抗焦虑特性。

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摘要

Anxiolytic properties may be a crucial feature of newer antipsychotics associated with the improvement of negative symptoms in schizophrenic patients. The indole alkaloid alstonine acts as an atypical antipsychotic in behavioral models, but differs in its dopamine and serotonin binding profile. The purpose of this study was to verify if alstonine possesses anxiolytic properties in mice. The hole-board and light/dark models were used; moreover, the participation of D(1), 5-HT(2), NMDA and gamma-aminobutyric acid (GABA) receptors was likewise investigated. Alstonine clearly behaves as anxiolytic in both hole-board and light/dark situations. Pretreatment with the 5-HT(2A/2C) serotonin receptor antagonist ritanserin reverted the effects of alstonine in both the hole-board and light/dark models, suggesting the involvement of these receptors in the alstonine mechanism of action. The involvement of glutamate NMDA receptors should also be considered, given that alstonine partially reversed the increase in locomotion induced by MK-801 in the hole board, as well as MK-801-induced hyperlocomotion in motor activity apparatus.
机译：抗焦虑特性可能是与精神分裂症患者阴性症状改善相关的新型抗精神病药的重要特征。在行为模型中，吲哚生物碱类阿斯丁宁可作为非典型的抗精神病药，但其多巴胺和5-羟色胺的结合特征不同。这项研究的目的是验证醛固酮在小鼠中是否具有抗焦虑特性。使用孔板和明暗模型。此外，同样研究了D（1），5-HT（2），NMDA和γ-氨基丁酸（GABA）受体的参与。显然，在孔板和明/暗情况下，精氨酸都具有抗焦虑作用。 5-HT（2A / 2C）5-羟色胺受体拮抗剂利坦色林的预处理在孔板模型和亮/暗模型中均还原了醛固酮的作用，表明这些受体参与了醛固酮的作用机制。还应考虑谷氨酸NMDA受体的参与，因为阿尔斯通能部分逆转MK-801在孔板上引起的运动增加，以及MK-801在运动活动装置中引起的运动过度。

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