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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Androgens in the hippocampus can alter, and be altered by, ictal activity.
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Androgens in the hippocampus can alter, and be altered by, ictal activity.

机译：海马中的雄激素可以改变，并且可以被眼动活动改变。

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Steroid hormones, such as androgens, can modulate seizure processes. This review summarizes prior research and presents new data that support the role of androgens in modulating seizure processes. Testosterone, the primary endogenous androgen, has antiseizure effects in people and in animal models of epilepsy. Furthermore, testosterone's antiseizure effects may involve actions of its 5alpha-reduced metabolite and neuroactive steroid, 5alpha-androstane-3alpha,17beta-diol (3alpha-diol). The hippocampus is a target for androgen action and is involved in many types of seizure disorder. Data suggest that actions of androgens in the hippocampus may be important for androgens' antiseizure effects. Interestingly, there may also be a reciprocal relationship between androgens and seizures. Ictal activity can alter the gonadal responsiveness of people with epilepsy and in animal models of seizure disorder. Thus, this paper will review data in support of androgens' antiseizure effects. Further understanding of androgens' role in seizure processes is important for potential therapeutic effects.
机译：类固醇激素，例如雄激素，可以调节癫痫发作过程。这篇综述总结了先前的研究，并提出了新的数据来支持雄激素在调节癫痫发作过程中的作用。睾丸激素是主要的内源性雄激素，对人和癫痫动物模型具有抗癫痫作用。此外，睾丸激素的抗癫痫作用可能涉及其5α-还原代谢产物和神经活性类固醇5α-雄甾烷3α，17β-二醇（3α-二醇）的作用。海马是雄激素作用的靶标，并参与多种类型的癫痫发作。数据表明，雄激素在海马中的作用可能对雄激素的抗癫痫作用很重要。有趣的是，雄激素与癫痫发作之间也可能存在相互关系。短暂的活动可以改变癫痫患者和癫痫发作动物模型的性腺反应能力。因此，本文将回顾支持雄激素抗癫痫作用的数据。进一步了解雄激素在癫痫发作过程中的作用对于潜在的治疗效果很重要。

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