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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effects of amphetamine, dexfenfluramine, diazepam, and dietary manipulations on responding reinforced by stimuli paired with food in nonhuman primates.
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Effects of amphetamine, dexfenfluramine, diazepam, and dietary manipulations on responding reinforced by stimuli paired with food in nonhuman primates.

机译：非人灵长类动物中苯丙胺，右芬氟拉明，地西epa和饮食操作对刺激和食物强化反应的响应。

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摘要

The purpose of this study was to determine how stimuli paired with food alters the effects of pharmacological and dietary manipulations on food intake. Responding of baboons was studied using a schedule of reinforcement that simulated food 'seeking' and food 'taking'. Under one condition, responding during the initial seeking component was reinforced by flashing lights that were paired with food delivery during the latter-taking component. Under another condition, responding during seeking components was reinforced by a 1-s time out that was paired with food delivery during the latter-taking component. Dexfenfluramine (DFEN) decreased responding within seeking and taking components under both conditions. Diazepam (DZP) increased responding within seeking and taking components under both conditions. Amphetamine (AMPH) increased responding within seeking components under the flashing-light condition, but did not alter responding within seeking components under the 1-s time-out condition. AMPH decreased responding within taking components under both conditions. As observed with AMPH, caloric prefeeding also increased responding within seeking components only under the flashing-light condition. As observed with DZP, acute deprivation also increased responding within seeking and taking components under both conditions. The effects of AMPH and caloric prefeeding on food seeking are dependent upon the type of stimuli, paired with primary reinforcement.
机译：这项研究的目的是确定刺激与食物配对如何改变药理和饮食操作对食物摄入的影响。使用模拟食物“寻找”和食物“摄取”的强化时间表研究了狒狒的反应。在一种情况下，初始搜寻部分期间的响应通过闪光灯闪烁而增强，后者与后一个拍摄部分中的食物输送配对。在另一种条件下，在寻找组件时的响应通过1-s超时得到加强，该超时与在后者获取组件期间的食物交付相匹配。两种情况下，右芬氟拉明（DFEN）的寻找和服用成分内的响应均降低。地西p（DZP）在两种情况下都提高了寻求和服用成分的反应性。苯丙胺（AMPH）在闪光条件下提高了寻找组分内的响应，但在1秒超时条件下并未改变寻求组分内的响应。在两种情况下，AMPH都会降低服用成分的反应。正如使用AMPH所观察到的那样，仅在闪光灯条件下，热量预给料也增加了寻找组件内的响应。正如DZP所观察到的，在两种情况下，急性剥夺也增加了寻求和服用成分的反应。 AMPH和热量预饲对觅食的影响取决于刺激的类型以及主要的强化作用。

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