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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Reinforcing effects of triazolam in sedative abusers: correlation of drug liking and self-administration measures.
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Reinforcing effects of triazolam in sedative abusers: correlation of drug liking and self-administration measures.

机译：三唑仑在镇静剂滥用者中的增强作用：喜欢毒品和自我管理措施的相关性。

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Six male subjects with histories of sedative abuse were allowed to orally self-administer a maximum of 18 color-coded triazolam and placebo capsules during daily 3-h sessions. The schedule of reinforcement was a signaled fixed-interval 10-min schedule in which triazolam and placebo were concurrently available as mutually exclusive choices. Triazolam was shown to be a reinforcer in four of the six subjects. The two subjects who did not self-administer triazolam in preference to placebo also had lesser histories of drug dependence. Self-administration of triazolam (0.125 or 0.25 mg per capsule) was generally stable over 7-10 days. Manipulations of triazolam dose (0.0312-0.25 mg) per capsule in two subjects showed that the number of capsules self-administered was inversely related to capsule dose. Subject ratings of drug liking obtained from experimenter-administered doses of triazolam were correlated with self-administration behavior occurring 1-7 days later. Of the subject ratings, next day ratings obtained on the day after dosing resulted in significant correlations whereas same day ratings obtained while subjects were under the influence of triazolam did not. These results have important implications for abuse liability prediction and suggest that next day ratings have greater predictive validity than measures collected while subjects are under the influence of benzodiazepines.
机译：在每天的3小时疗程中，允许6名具有镇静药物滥用史的男性受试者口服最多18个颜色编码的三唑仑和安慰剂胶囊。加强计划是一个有信号的固定间隔10分钟计划，其中三唑仑和安慰剂可以同时作为互斥选择使用。三唑仑被证明是六名受试者中四名的补强药。没有优先于安慰剂自行服用三唑仑的两名受试者也有较少的药物依赖史。三唑仑（0.125或0.25 mg /胶囊）的自我给药通常在7到10天内稳定。在两名受试者中对每个胶囊的三唑仑剂量（0.0312-0.25 mg）进行操作显示，自我给药的胶囊数量与胶囊剂量成反比。从实验者给予的三唑仑剂量获得的药物喜欢的受试者评分与1-7天后发生的自我给药行为相关。在受试者评级中，服药后第二天获得的次日评级具有显着的相关性，而受试者在三唑仑的影响下获得的当天评级则没有显着相关性。这些结果对滥用责任的预测具有重要意义，并表明，与受试者在苯二氮卓类药物的影响下收集到的数据相比，第二天的评分具有更大的预测效度。

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