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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effect of fluoxetine on learning and memory involves multiple 5-HT systems.
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Effect of fluoxetine on learning and memory involves multiple 5-HT systems.

机译：氟西汀对学习和记忆的影响涉及多个5-HT系统。

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摘要

Diverse evidence suggests that 5-HT uptake blockers enhance learning and memory. However, there is no information about the mechanisms of action involved in such effects. The aim of the present work was to investigate the nature of the receptors involved in the effects of fluoxetine on learning. Therefore, a dose-response curve of posttraining injection (intraperitoneal) of fluoxetine was carried out in an associative learning task (auto-shaping). Fluoxetine or the vehicle was injected 10 min after 5-HT antagonists: (+/-)-pindolol, (+/-)-propanolol, NAN-190, ketanserin, ritanserin, mesulergine, MDL 72222, or SDZ 205-557. Presynaptic activity was eliminated by means of chloroamphetamine pretreatment. Scopolamine (an anticholinergic) and dizocilpine (a noncompetitive NMDA receptor antagonist) were also used. Results showed that fluoxetine enhanced learning of the conditioned response (CR) in a dose-dependent fashion. All 5-HT antagonists had no effects by themselves but inhibited the effects of fluoxetine at different degrees. Decrement of CR produced by scopolamine was reversed by fluoxetine. Dizocilpine did not affect CR but prevented the effects of fluoxetine. The present findings suggest that the actions of fluoxetine on learning are due to an interaction with multiple receptors of postsynaptic nature.
机译：各种各样的证据表明5-HT摄取阻滞剂可增强学习和记忆能力。但是，没有有关这种效应所涉及的作用机制的信息。当前工作的目的是研究参与氟西汀对学习的影响的受体的性质。因此，在联合学习任务（自动整形）中，进行了氟西汀训练后注射（腹膜内）的剂量反应曲线。在5-HT拮抗剂：（+/-）-潘多洛尔，（+/-）-丙醇，NAN-190，酮色林，利坦色林，美司麦林，MDL 72222或SDZ 205-557后10分钟注射氟西汀或赋形剂。通过氯苯丙胺预处理消除了突触前的活性。还使用了东pol碱（一种抗胆碱能药）和地佐西平（一种非竞争性NMDA受体拮抗剂）。结果表明，氟西汀以剂量依赖的方式增强了条件反应（CR）的学习。所有5-HT拮抗剂本身无作用，但在不同程度上抑制氟西汀的作用。氟西汀逆转了东pol碱产生的CR的下降。地佐西平不影响CR，但预防了氟西汀的作用。本研究结果表明氟西汀对学习的作用是由于与突触后性质的多个受体的相互作用。

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