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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Liver alcohol dehydrogenase activity and ethanol levels during chronic ethanol intake in pregnant rats and their offspring.
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Liver alcohol dehydrogenase activity and ethanol levels during chronic ethanol intake in pregnant rats and their offspring.

机译：怀孕大鼠及其后代长期摄入乙醇期间肝酒精脱氢酶活性和乙醇水平。

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摘要

The effects of chronic alcohol intake on the ethanol levels in body fluids (blood, amniotic fluid, and fetal intragastric content), hepatic alcohol dehydrogenase (ADH) activity, isoenzyme distribution, and hepatic zinc levels were studied in pregnant rats at term (19 and 21 days), in their offspring at fetal, perinatal, and weaned stages, and in adult virgin rats. Three experimental groups were studied: 1) the alcohol group received ethanol in drinking water (from 10% to 25% over 2 months), 2) the fibre diet group was undernourished on a hypocaloric diet, to assess the effects of malnutrition associated with chronic alcohol intake, and 3) the control group received no alcohol and normal diet. A gradient of increasing ethanol concentrations was found in fetal blood, amniotic fluid, and fetal intragastric contents with respect to maternal blood. A decrease in ADH activity was found in alcohol-consuming pregnant rats compared to controls. This was related neither to liver ADH isoenzyme distribution nor tochanges in hepatic zinc levels. Chronic alcohol consumption in pregnant rats produced high ethanol accumulation in fetal fluids and changes in the liver ADH activity depending on the physiological situation (pregnancy, development, virgin state).
机译：在足月（19岁和19岁），研究了长期摄入酒精对怀孕大鼠体液中乙醇含量（血液，羊水和胎儿胃内含量），肝醇脱氢酶（ADH）活性，同工酶分布和肝锌水平的影响。 21天），在胎儿，围产期和断奶期的后代中以及成年处女大鼠中。研究了三个实验组：1）酒精组在饮用水中接受乙醇（两个月内从10％到25％），2）纤维饮食组在低热量饮食中营养不足，以评估营养不良与慢性饮食相关的影响饮酒，以及3）对照组不饮酒且饮食正常。相对于母体血液，在胎儿血液，羊水和胎儿胃内内容物中发现了乙醇浓度增加的梯度。与对照组相比，在饮酒的怀孕大鼠中发现ADH活性降低。这既与肝脏ADH同工酶的分布无关，也与肝锌水平的变化无关。根据生理状况（怀孕，发育，原始状态），怀孕大鼠的长期饮酒会导致胎儿液体中乙醇的大量积累，以及肝脏ADH活性的变化。

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