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Stimulus control of addictive behavior: persistence in the presence and absence of a drug.

机译:刺激成瘾行为的控制:持续存在和不存在药物。

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Rats were exposed daily to a food schedule-induced polydipsia condition, in which water and 0.16 mg/ml cocaine solution were available concurrently, with the cocaine solution indicated by a discriminative stimulus (SD) light. The cocaine solution was preferred, and the preference was maintained when the SD was gradually eliminated by fading its intensity. For a second group, if cocaine concentration was the stimulus gradually eliminated, preference for the resulting solution (water) indicated by the SD was stably maintained. For two additional groups, if either the light SD or the cocaine stimulus was removed abruptly rather than gradually, few animals retained preferences. These studies reveal the importance of establishing strong stimulus control for the initiation and persistence of drug abuse behavior.
机译:每天使大鼠暴露于食物计划诱发的多饮症,其中可同时使用水和0.16 mg / ml可卡因溶液,并通过判别性刺激(SD)光指示可卡因溶液。可卡因溶液是优选的,当通过逐渐减弱其强度逐渐消除SD时,可卡因保持了优先级。对于第二组,如果逐渐消除了可卡因浓度的刺激,则可以稳定地保持对SD指示的所得溶液(水)的偏爱。对于另外两个组,如果突然移除而不是逐渐移除轻度SD或可卡因刺激,则几乎没有动物会保持偏好。这些研究揭示了建立强有力的刺激控制对药物滥用行为的引发和持久性的重要性。

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