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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effects of estradiol and tamoxifen on feeding, fattiness, and some endocrine criteria in hypothalamic obese hens.
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Effects of estradiol and tamoxifen on feeding, fattiness, and some endocrine criteria in hypothalamic obese hens.

机译：雌二醇和他莫昔芬对下丘脑肥胖母鸡的摄食，脂肪和某些内分泌标准的影响。

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摘要

In White Leghorn hens, basomedial hypothalamic (BMH) lesions result in two syndromes: a) obese, functionally castrated (OFC) hens, in which both the ventromedial hypothalamic nucleus (VMH) and the mammillary nuclei are damaged and plasma estrogen is very low; and b) obese laying (OL) hens, which have normal levels of plasma estrogen and are less obese than the former, and whose lesion is limited to the VMH. In the present study, the involvement of estrogen in regulation of fattiness and energy metabolism was assayed in OFC, OL, and control (CONT) hens. BMH lesions were made at 13 weeks of age. When the typical syndromes reached the static phase, 20 weeks later, CONT, OFC, and OL hens were divided into three subgroups and were injected for 10 weeks on each alternate day, with either 10 mg tamoxifen (TAM)/kg, 2 mg estradiol benzoate (E2)/kg, or the vehicle, corn oil (0.5 ml). E2 raised plasma total lipids and reduced plasma glucose, insulin, and hematocrit in all treated hens, and increased liver weight in OL and OFC, but not in CONT hens. In OFC hens only, E2 reduced food intake (FI) and fattiness. In OL and CONT hens, E2 increased plasma T3, but raised the resting metabolic rate (RMR) only in CONT ones. In OFC hens, E2 reduce plasma T3 and T4 without affecting RMR. E2 reduced comb weight and egg production in CONT and more severely in OL hens. In the latter, E2 diminished ovarian and oviduct weights, whereas in OFC hens it increased the size of the atrophied oviduct. TAM had no visible effect on OFC hens.(ABSTRACT TRUNCATED AT 250 WORDS)
机译：在白来亨鸡母鸡中，丘脑下丘脑（BMH）病变导致两种综合症：a）肥胖，功能cast割（OFC）母鸡，其中腹膜下丘脑核（VMH）和乳突核均受损，血浆雌激素非常低; b）肥胖的母鸡，血浆雌激素水平正常，且肥胖程度低于前者，且病变仅限于VMH。在本研究中，在OFC，OL和对照（CONT）母鸡中检测了雌激素参与脂肪和能量代谢调节的过程。 BMH病变发生在13周龄。当典型的综合症到达静止期时，在20周后，将CONT，OFC和OL母鸡分为三个亚组，并每隔一天注射10周他莫昔芬（TAM）/ kg，2 mg雌二醇苯甲酸酯（E2）/ kg，或赋形剂玉米油（0.5 ml）。 E2可提高所有母鸡的血浆总脂质水平，降低血浆葡萄糖，胰岛素和血细胞比容，而OL和OFC则增加肝脏重量，但CONT母鸡则没有。仅在OFC母鸡中，E2会减少食物摄入（FI）和脂肪。在OL和CONT母鸡中，E2增加血浆T3，但仅在CONT母鸡中增加静息代谢率（RMR）。在OFC母鸡中，E2可降低血浆T3和T4，而不会影响RMR。 E2降低了CONT中的精梳重量和产蛋量，OL母鸡中更严重。在后者中，E2减少了卵巢和输卵管的重量，而在OFC母鸡中，它增加了萎缩性输卵管的大小。 TAM对OFC母鸡没有可见的影响（摘要以250字截短）

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