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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Distribution and clearance of cocaine in brain is influenced by genetics.
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Distribution and clearance of cocaine in brain is influenced by genetics.

机译：脑中可卡因的分布和清除受遗传学影响。

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The purpose of this study was to examine the pharmacokinetics of cocaine in two inbred mouse strains, C57BL/6 (B6) and DBA/2 (D2). Male and female mice were administered 30 mg kg(-1) cocaine IP and killed after 5, 15, 30, or 60 minutes postinjection. Brains were removed quickly and assayed for total brain cocaine concentration. Quantification of cocaine was conducted using gas chromatography and mass spectrometry. The results of this study revealed a strain difference in total brain cocaine kinetics. Specifically, we observed that at 5 min onward, B6 mice cleared cocaine from the brain with a t1/2 estimated at 22.3 min, while distribution in D2 mice appeared to be incomplete until 15 min with a subsequent t1/2 estimated at 11.2 min. These results show that despite faster clearance by D2 mice, the prolonged time to distribution in this strain may help explain why D2 mice show initial greater locomotor activation by cocaine, compared to B6s.
机译：这项研究的目的是检查可卡因在两种近交小鼠品系C57BL / 6（B6）和DBA / 2（D2）中的药代动力学。雄性和雌性小鼠注射30 mg kg（-1）可卡因IP，并在注射后5、15、30或60分钟后杀死。快速取出大脑，并测定其总可卡因浓度。使用气相色谱法和质谱法对可卡因进行定量。这项研究的结果揭示了总脑可卡因动力学中的一种应变差异。具体来说，我们观察到在5分钟之后，B6小鼠从大脑清除了可卡因，t1 / 2估计为22.3分钟，而D2小鼠中的分布似乎不完整，直到15分钟，随后的t1 / 2估计为11.2分钟。这些结果表明，尽管D2小鼠的清除速度更快，但该菌株中较长的分布时间可能有助于解释为什么D2小鼠与B6s相比，最初显示出可卡因具有更大的运动激活能力。

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