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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Mismatch negativity in tobacco-naive cannabis users and its alteration with acute nicotine administration
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Mismatch negativity in tobacco-naive cannabis users and its alteration with acute nicotine administration

机译：未使用烟草的大麻使用者的失配阴性和急性尼古丁给药后的改变

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Chronic cannabis use may interact with factors, such as age of onset of cannabis use, family history, and genetic factors, to elicit schizophrenia (SZ)-like symptoms, including sensory and cognitive deficits. However, evidence of a relationship between cannabis use and cognitive impairment is confounded by concomitant use of tobacco. The objective of this study was to compare tobacco-naive cannabis users with individuals without a history of tobacco/cannabis use on the auditory mismatch negativity (MMN) event-related potential (ERP), a neural measure of auditory deviance detection which is diminished in SZ. An exploratory arm of the study, conducted within a randomized, double-blind, placebo controlled design, examined the acute effects of nicotine gum (6 mg) on MMN in cannabis users. MMN was recorded in response to 5 deviant stimuli within an optimal MMN paradigm in 44 healthy, non-tobacco smoking volunteers aged 18-26. Cannabis users (n = 21) started smoking cannabis prior to age 17, at least 1 joint per month. To examine the effects of chronicity, users were grouped into relatively heavy long-term (HLT; n = 11) users and light short-term (LST; n = 10) users. Impaired deviance detection was shown in cannabis users vs. nonusers as reflected by a smaller MMN to duration deviants. Chronicity of use was also associated with MMN alterations, as HLTs displayed a reduced duration and gap MMN vs. LSTs. Compared with placebo, nicotine treatment enhanced select MMN deviants in cannabis user subgroups. As deficits associated with early and persistent cannabis use are similar to those seen in SZ, these dose-dependant disturbances in early sensory processing with cannabis use may be one cognitive pathway which mediates an increased risk for SZ in vulnerable youth, and be influenced by concurrent cigarette smoking behavior. (C) 2015 Elsevier Inc. All rights reserved.
机译：长期使用大麻可能会与各种因素相互作用，例如开始使用大麻的年龄，家族病史和遗传因素，从而引发类似精神分裂症（SZ）的症状，包括感觉和认知缺陷。然而，同时使用烟草混淆了大麻使用与认知障碍之间关系的证据。这项研究的目的是比较未使用过烟草的大麻使用者与没有使用过烟草/大麻历史的个人在听觉失配阴性（MMN）事件相关电位（ERP）上的差异，这是听觉异常检测的一种神经测量方法，在深圳该研究的一个探索性小组在一项随机，双盲，安慰剂对照的设计中进行了研究，研究了尼古丁胶（6 mg）对大麻使用者中MMN的急性作用。在44位18-26岁的健康，非吸烟志愿者中，MMN被记录为对最佳MMN范式中的5个异常刺激的反应。大麻使用者（n = 21）在17岁之前开始吸烟，每月至少吸烟1次。为了检查慢性病的影响，将用户分为长期（HLT; n = 11）和长期（LST; n = 10）。较小的MMN对持续时间的偏差反映出，大麻使用者与非使用者之间的偏差检测受损。长期使用还与MMN改变有关，因为HLT与LST相比，MMN的持续时间和间隔减少。与安慰剂相比，尼古丁治疗增强了大麻使用者亚组中精选的MMN变异。由于与早期和持续使用大麻有关的缺陷与在SZ中所见的缺陷相似，因此在使用大麻进行早期感官加工过程中，这些剂量依赖性干扰可能是介导易感青少年SZ风险增加的一种认知途径，并受到同时发生的影响。吸烟行为。 （C）2015 Elsevier Inc.保留所有权利。

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