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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >NMDA and D1 receptors are involved in one-trial tolerance to the anxiolytic-like effects of diazepam in the elevated plus maze test in rats
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NMDA and D1 receptors are involved in one-trial tolerance to the anxiolytic-like effects of diazepam in the elevated plus maze test in rats

机译：在升高的迷宫试验中，NMDA和D1受体参与了对地西m抗焦虑样作用的一审耐受

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The elevated plus maze (EPM) test is used to examine anxiety-like behaviors in rodents. One interesting phenomenon in the EPM test is one-trial tolerance (OTT), which refers to the reduction in the anxiolylic-like effects of benzodiazepines when rodents are re-exposed to the EPM. However, the underlying mechanism of OTT is still unclear. In this study, we reported that OTT occurred when re-exposure to the EPM (trial 2) only depended on the prior experience of the EPM (trial 1) rather than diazepam treatment. This process was memory-dependent, as it was prevented by the N-methyl-D-aspartate (NMDA) receptors antagonist MK-801 1.5 h before trial 2. In addition, OTT was maintained for at least one week but was partially abolished after an interval of 28 days. Furthermore, the administration of the D1-like receptors agonist SKF38393 to the bilateral dorsal hippocampus largely prevented OTT, as demonstrated by the ability of the diazepam treatment to produce significant anxiolytic-like effects in trial 2 after a one-day interval. These findings suggest that OTT to the EPM test may occur via the activation of NMDA receptors and the inactivation of D1-like receptors in certain brain regions, including the hippocampus. (C) 2015 Elsevier Inc. All rights reserved.
机译：高架迷宫（EPM）测试用于检查啮齿动物的焦虑样行为。 EPM测试中的一个有趣现象是单试验耐受性（OTT），这是指将啮齿动物重新暴露于EPM后苯并二氮杂卓类抗焦虑药的作用降低。但是，OTT的潜在机制仍不清楚。在这项研究中，我们报道了当再次暴露于EPM（试验2）时OTT的发生仅取决于EPM的先前经验（试验1），而不是地西epa的治疗。该过程是记忆依赖性的，因为在试验2前1.5小时，N-甲基-D-天冬氨酸（NMDA）受体拮抗剂MK-801阻止了该过程。此外，OTT至少维持了一个星期，但在OTT后被部分取消了间隔28天。此外，向双侧背侧海马施用D1样受体激动剂SKF38393在很大程度上预防了OTT，这是由地西one治疗在一天的间隔后产生显着的抗焦虑药作用的能力所证实的。这些发现表明，对EPM测试的OTT可能是通过NMDA受体的激活和某些大脑区域（包括海马体）的D1样受体的失活而发生的。 （C）2015 Elsevier Inc.保留所有权利。

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